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TNFAIP3 [cytosol]
Stable Identifier
R-MMU-688989
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q60769
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
Negative regulators of DDX58/IFIH1 signaling (Mus musculus)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Mus musculus)
TAX1BP1:TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TAX1BP1:TNFAIP3:TBK1/IKBKE [cytosol] (Mus musculus)
TAX1BP1:TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Mus musculus)
NOD1/2 Signaling Pathway (Mus musculus)
TNFAIP3 (A20) deubiquitinates RIP2 (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ovarian tumor domain proteases (Mus musculus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1:K48polyUb-TRAF6 [cytosol] (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3:K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3:RIPK1 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3 (A20) deubiquitinates RIP2 (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3 (A20) ubiquitinates RIPK1 (Mus musculus)
TNFAIP3:K48polyUb-RIPK1 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3:RIPK1 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1:K63polyUb-TRAF6 [cytosol] (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Mus musculus)
OTUD7B,TNFAIP3,ZRANB1 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNIPs bind TNFAIP3 (A20) (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3:TNIPs [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
K63polyUb-RIPK1 is deubiquitinated (Mus musculus)
RIPK1 deubiquitinases [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Mus musculus)
TAX1BP1:TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Mus musculus)
TAX1BP1:TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Mus musculus)
TAX1BP1:TNFAIP3 [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFR1-induced NF-kappa-B signaling pathway (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
RIPK1 deubiquitinases [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Mus musculus)
RIPK1 deubiquitinases [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
TNFR1-induced proapoptotic signaling (Mus musculus)
TRADD:TRAF2:RIP1 binds FADD (Mus musculus)
RIPK1 deubiquitinases [cytosol] (Mus musculus)
TNFAIP3 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q60769
Reference Genes
BioGPS Gene:21929
ENSEMBL:ENSMUSG00000019850
KEGG:mmu:21929
Monarch:21929
NCBI Gene:21929
UCSC:Q60769
Reference Transcript
RefSeq:NM_009397.3
RefSeq:XM_006512702.2
Other Identifiers
10368144
1433699_at
17239597
21929
4321411
4379164
4387355
4661386
4663826
4681362
4694220
4714634
4744026
4775557
4787543
4816894
4839856
5109916
5117910
5120850
5162494
5193118
5252603
5285743
5298735
5316098
5318451
5362610
5367306
5401200
5535012
99392_at
A_52_P412417
A_55_P2053838
GE33824
GO:0001922
GO:0002020
GO:0002237
GO:0002315
GO:0002376
GO:0002632
GO:0002634
GO:0002637
GO:0002677
GO:0003677
GO:0003824
GO:0004842
GO:0004843
GO:0005515
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0006508
GO:0006915
GO:0006954
GO:0007010
GO:0008234
GO:0008270
GO:0009611
GO:0010507
GO:0012501
GO:0016477
GO:0016579
GO:0016740
GO:0016787
GO:0019900
GO:0030154
GO:0030177
GO:0031397
GO:0032495
GO:0032691
GO:0032703
GO:0032715
GO:0032720
GO:0034115
GO:0034140
GO:0034148
GO:0035523
GO:0035871
GO:0042802
GO:0043124
GO:0043130
GO:0043226
GO:0045088
GO:0045732
GO:0045736
GO:0045824
GO:0046872
GO:0048662
GO:0048870
GO:0050728
GO:0050869
GO:0070301
GO:0070429
GO:0070433
GO:0070530
GO:0070536
GO:0070936
GO:0071108
GO:0071222
GO:0071947
GO:0072573
GO:0072666
GO:0140096
GO:1902042
GO:1990168
GO:2000347
GO:2000349
GO:2000352
GO:2001237
ILMN_1252202
Msa.1406.0_at
mMC002633
Participates
as a component of
TNFAIP3:K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNFAIP3:K48polyUb-RIPK1 [cytosol] (Mus musculus)
TNFAIP3:RIPK1 [cytosol] (Mus musculus)
TNFAIP3:TNIPs [cytosol] (Mus musculus)
TAX1BP1:TNFAIP3 [cytosol] (Mus musculus)
as an input of
TNIPs bind TNFAIP3 (A20) (Mus musculus)
as a member of
OTUD7B,TNFAIP3,ZRANB1 [cytosol] (Mus musculus)
RIPK1 deubiquitinases [cytosol] (Mus musculus)
Inferred From
TNFAIP3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006512765.1
,
NP_033423.3
ENSEMBL
ENSMUSP00000101167
,
ENSMUST00000105527
,
ENSMUST00000019997
,
ENSMUSP00000019997
PRO
Q60769
GlyGen
Q60769
MGI
1196377
PDB
5DQ6
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9WUU8
1
Tnip1 [cytosol]
(R-MMU-5690853)
0.736
4
UniProt:P39429
5
Traf2 [nucleoplasm]
(R-MMU-8862199)
Traf2 [nucleoplasm]
(R-MMU-8862194)
Traf2 [cytosol]
(R-MMU-8862193)
Traf2 [cytosol]
(R-MMU-6782848)
Traf2 [cytosol]
(R-MMU-66370)
0.547
3
UniProt:Q9QYK7 RNF11
0.527
3
UniProt:Q9CYZ8 SSBP2
0.508
2
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.499
2
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