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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
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Developer's Zone
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MDP:NOD2 oligomer [cytosol]
Stable Identifier
R-MMU-708350
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-17 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Mus musculus)
NOD1/2 Signaling Pathway (Mus musculus)
Activated NOD oligomer recruites RIP2 (RICK) (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
Activated NOD2 oligomerizes (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
CYLD deubiquitinates NEMO (Mus musculus)
PAMP:NOD oligomer:RIP2:K63-Ub-K285-NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
K63 polyubiquitinated RIP2 associates with the TAK1 complex (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
RIP2 binds NEMO (Mus musculus)
PAMP:NOD oligomer:RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
RIP2 induces K63-linked ubiquitination of NEMO (Mus musculus)
PAMP:NOD oligomer:RIP2:K63-Ub-K285-NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
RIP2 is K63 polyubiquitinated (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
TAK1 is activated (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
TNFAIP3 (A20) deubiquitinates RIP2 (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)
Activated TAK complexes [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ovarian tumor domain proteases (Mus musculus)
TNFAIP3 (A20) deubiquitinates RIP2 (Mus musculus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Mus musculus)
PAMP:NOD oligomer:RIP2 [cytosol] (Mus musculus)
PAMP:NOD oligomer [cytosol] (Mus musculus)
MDP:NOD2 oligomer [cytosol] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 6
MDP:NOD2 [cytosol]
(Mus musculus)
Participates
as an output of
Activated NOD2 oligomerizes (Mus musculus)
as a member of
PAMP:NOD oligomer [cytosol] (Mus musculus)
Inferred From
MDP:NOD2 oligomer [cytosol]
(Homo sapiens)
© 2024
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