Reactome | Hnrnpa1 [nucleoplasm]

Hnrnpa1 [nucleoplasm]

Stable Identifier

R-MMU-71927

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

HNRNPA1, P49312

Locations in the PathwayBrowser

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Metabolism of RNA (Mus musculus)

- Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
  - Formation of pre-mRNPs (Mus musculus)
    - Alternative Splicing Factors [nucleoplasm] (Mus musculus)
      - shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
      - Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
  - mRNA Splicing (Mus musculus)
    - mRNA Splicing - Major Pathway (Mus musculus)
      - Formation of the Spliceosomal B complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal Bact complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal C complex containing intron lariat (Mus musculus)
        
        Spliceosomal B* complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal C complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal C* complex (Mus musculus)
        
        Spliceosomal C complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal C* complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal E complex (Mus musculus)
        
        Spliceosomal E complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal P complex and exon ligation (Mus musculus)
        
        Spliceosomal C* complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal P complex [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpa1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P49312

Gene Names

Hnrnpa1

Reference Genes

BioGPS Gene:15382 Hnrnpa1

ENSEMBL:ENSMUSG00000046434

KEGG:mmu:15382 Hnrnpa1

Monarch:15382 Hnrnpa1

NCBI Gene:15382 Hnrnpa1

UCSC:P49312 Hnrnpa1

Reference Transcript

RefSeq:NM_010447.5 Hnrnpa1

Other Identifiers

100371_at

10427310

10427885

10454411

10597969

10602173

1423531_a_at

1430019_a_at

1430020_x_at

1436549_a_at

1455305_x_at

15382

17315546

17532524

4305572

4466220

4469803

4472724

4518880

4542763

4564269

4603758

4662450

4694313

4722373

4740197

4777427

4893624

4911953

4918143

4962585

4977824

4981162

4986597

4995131

5035029

5053765

5066941

5098689

5101287

5112476

5189349

5194016

5194249

5227319

5265765

5392473

5395102

5402262

5414770

5415226

5439083

5503579

5560674

5586077

5586788

5607793

97272_at

A_51_P296940

A_51_P400784

A_52_P232433

A_55_P2029842

GE35557

GO:0000380

GO:0000398

GO:0003676

GO:0003677

GO:0003697

GO:0003723

GO:0003727

GO:0003729

GO:0003730

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0006397

GO:0006913

GO:0008380

GO:0010628

GO:0016071

GO:0033592

GO:0035198

GO:0035865

GO:0043226

GO:0045202

GO:0045760

GO:0051028

GO:0051168

GO:0051170

GO:0071013

GO:1903936

GO:1990814

GO:1990825

GO:1990826

GO:1990904

ILMN_1244536

ILMN_2638757

ILMN_2712751

ILMN_2712755

ILMN_3024068

ILMN_3096701

d86729_s_at

mMC020420

mMR026290

Participates

as a member of

shuttling HNRNPs [nucleoplasm] (Mus musculus)

as a component of

FGFR2 IIIc-specific splicing complex [nucleoplasm] (Mus musculus)

as an input of

PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Mus musculus)

Inferred From

HNRNPA1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_034577.1

ENSEMBL

ENSMUSP00000084609, ENSMUST00000230171, ENSMUST00000231141, ENSMUSP00000155311, ENSMUST00000087351, ENSMUSP00000155833

PRO

P49312

GlyGen

P49312

MGI

104820

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92945 KHSRP	4	p-S193-KHSRP [nucleoplasm] (R-HSA-450452) p-T692-KHSRP [cytosol] (R-HSA-451177) p-S193-KHSRP [cytosol] (R-HSA-450505) KSRP [cytosol] (R-HSA-450485)	0.482	2
UniProt:Q3U0V1 Khsrp	5	phospho-Khsrp [nucleoplasm] (R-MMU-450452) p-T692-Khsrp [cytosol] (R-MMU-451155) Khsrp [cytosol] (R-MMU-451141) phospho-Khsrp [cytosol] (R-MMU-450505) Khsrp [cytosol] (R-MMU-450485)	0.462	2

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