Reactome | Sf3a1 [nucleoplasm]

Sf3a1 [nucleoplasm]

Stable Identifier

R-MMU-71962

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

SF3A1, Q8K4Z5

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
  - mRNA 3'-end processing (Mus musculus)
    - mRNA Polyadenylation (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
      - Core CPA complex binds capped pre-mRNA (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
      - PP1 dephosphorylates RNA Pol II (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
      - RBBP6 activates CPSF complex (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
  - mRNA Splicing (Mus musculus)
    - mRNA Splicing - Major Pathway (Mus musculus)
      - Formation of the Spliceosomal B complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal B* complex (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal Bact complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
        
        U2 snRNP [nucleoplasm] (Mus musculus)
        
        SF3A [nucleoplasm] (Mus musculus)
        
        Sf3a1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8K4Z5

Gene Names

Sf3a1

Reference Genes

BioGPS Gene:67465 Sf3a1

ENSEMBL:ENSMUSG00000002129

KEGG:mmu:67465 Sf3a1

Monarch:67465 Sf3a1

NCBI Gene:67465 Sf3a1

UCSC:Q8K4Z5 Sf3a1

Reference Transcript

RefSeq:NM_026175.5 Sf3a1

Other Identifiers

10373873

117259_at

1419087_s_at

1446687_at

1449333_at

17246757

4316528

4325850

4425075

4466323

4523313

4534840

4538709

4572658

4632131

4637200

4789461

4810433

4834284

4875297

4935882

4947957

4968814

4984937

5033477

5079383

5185813

5214392

5310120

5415378

5474601

5554643

5579264

67465

96027_at

A_51_P504442

A_52_P569178

GE41127

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005684

GO:0005686

GO:0006396

GO:0006397

GO:0008380

GO:0016071

GO:0016607

GO:0045292

GO:0065003

GO:0071004

GO:0071005

GO:0071013

GO:1903241

ILMN_1215857

ILMN_2421345

ILMN_2630730

aa106955_s_at

mMC005388

mMR027064

Participates

as a component of

SF3A [nucleoplasm] (Mus musculus)

Inferred From

SF3A1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_080451.4

ENSEMBL

ENSMUST00000002198, ENSMUSG00000002129, ENSMUSP00000002198

PRO

Q8K4Z5

MGI

1914715

PDB

1WE7

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