Reactome | Rps16 [cytosol]

Rps16 [cytosol]

Stable Identifier

R-MMU-72337

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RPS16, P14131

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps16 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps16 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps16 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps16 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps16 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps16 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps16 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps16 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps16 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps16 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P14131 Rps16

Gene Names

Rps16

Chain

chain:1-146

Reference Genes

BioGPS Gene:20055 Rps16

KEGG:mmu:20055 Rps16

Monarch:20055 Rps16

NCBI Entrez Gene:20055 Rps16

UCSC:P14131 Rps16

Reference Transcript

RefSeq:NM_013647.2 Rps16

Other Identifiers

10534053

10551489

10578613

1416404_s_at

1437196_x_at

17453102

17475809

20055

4528088

4588228

4710329

4713930

4730855

4735499

4850803

4936631

5036642

5156544

5202672

5248991

5337368

5389363

5426668

5558754

97647_at

A_51_P416995

A_55_P1963061

A_55_P1963062

GE119732

GO:0000462

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0015935

GO:0022626

GO:0022627

GO:0032040

GO:0042274

GO:0045202

GO:0098793

GO:0098794

GO:0140236

GO:0140242

GO:1990830

GO:1990904

ILMN_1227972

ILMN_2692247

M11408_f_at

Msa.133.0_f_at

mMC024605

Participates

as a component of

Other forms of this molecule

Rps16 [nucleoplasm]

Rps16 [cytosol]

Inferred From

RPS16 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_038675.2

ENSEMBL

ENSMUSP00000103940, ENSMUST00000082134, ENSMUSG00000037563

PRO

P14131

GlyGen

P14131

MGI

98118

PDB

7LS1, 7CPU, 7CPV, 7LS2

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