Reactome | Rpl34 [cytosol]

Rpl34 [cytosol]

Stable Identifier

R-MMU-72458

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RPL34, Q9D1R9

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl34 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl34 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl34 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl34 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl34 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl34 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl34 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl34 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl34 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl34 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9D1R9 Rpl34

Gene Names

Rpl34

Chain

chain:1-117

Reference Genes

BioGPS Gene:619547 Rpl34

BioGPS Gene:68436 Rpl34

CTD Gene:619547 Rpl34

ENSEMBL:ENSMUSG00000062006.13 Rpl34

KEGG Gene (Mus musculus):68436 Rpl34

Monarch:619547 Rpl34

Monarch:68436 Rpl34

NCBI Gene:619547 Rpl34

NCBI Gene:68436 Rpl34

UCSC:Q9D1R9 Rpl34

Reference Transcript

Other Identifiers

10407319

10502196

10514173

10524018

10538963

1427875_a_at

1438655_a_at

17410381

17459453

4333840

4515269

4636577

4686749

4758321

4784948

4940865

5039530

5091290

5132571

5258678

5302761

5331462

5359284

5433291

619547

68436

96307_s_at

A_51_P243283

A_51_P243288

GO:0002181

GO:0003735

GO:0005198

GO:0005634

GO:0005730

GO:0005737

GO:0005739

GO:0005783

GO:0005829

GO:0005840

GO:0006412

GO:0022625

GO:0022626

GO:0043226

GO:0045202

GO:0098793

GO:0098794

GO:0140236

GO:0140242

GO:1990904

ILMN_2682218

aa541910_s_at

mMC025362

Participates

as a component of

Other forms of this molecule

Rpl34 [cytosol]

Inferred From

RPL34 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_001481222.1, NP_001005859.1, NP_001186279.1, NP_001274510.1, NP_081000.1

Ensembl

ENSMUST00000062601, ENSMUST00000079085, ENSMUSP00000078092, ENSMUSP00000142486, ENSMUST00000196202, ENSMUSG00000062006, ENSMUSP00000086614

PRO

Q9D1R9

MGI

1915686

PDB

7LS2, 7CPU, 6SWA, 7CPV, 7LS1

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