Reactome | Grb2 [cytosol]

Grb2 [cytosol]

Stable Identifier

R-MMU-74686

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

GRB2-1, Q60631

Locations in the PathwayBrowser for interactor UniProt:P22682 Cbl

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External Reference Information

External Reference

UniProt:Q60631 Grb2

Gene Names

Grb2

Chain

chain:1-217

Reference Genes

BioGPS Gene:14784 Grb2

KEGG:mmu:14784 Grb2

Monarch:14784 Grb2

NCBI Gene:14784 Grb2

UCSC:Q60631 Grb2

Reference Transcript

Participates

as a component of

as an input of

as an output of

PPTN11 dephosphorylates SPRY2 (Mus musculus)

as a member of

Other forms of this molecule

Grb2 [plasma membrane]

Grb2 [cytosol]

Inferred From

GRB2-1 [cytosol] (Homo sapiens)

GRB2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_032189.1, NP_001300865.1, NP_001300866.1

ENSEMBL

ENSMUSP00000102108, ENSMUSP00000102106, ENSMUST00000106497, ENSMUST00000106499, ENSMUSG00000059923, ENSMUSP00000021090, ENSMUST00000021090

ZINC - Substances

GRB2_MOUSE

ZINC target

Q60631

PRO

Q60631

MGI

95805

ZINC - Predictions - Purchasable

GRB2_MOUSE

PDB

1GBQ, 2GBQ, 3GBQ, 1GBR, 4GBQ

HMDB Protein

HMDBP13428

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98083 Shc1	19	phospho-Shc1 [cytosol] (R-MMU-162568) Shc1 [cytosol] (R-MMU-74680) phospho-Shc1 [cytosol] (R-MMU-912321) phospho-Shc1 [plasma membrane] (R-MMU-1169507) phospho-Shc1 [plasma membrane] (R-MMU-1169439) phospho-Shc1 [cytosol] (R-MMU-180276) phospho-Shc1 [cytosol] (R-MMU-74684) phospho-Shc1 [cytosol] (R-MMU-1433505) phospho-Shc1 [cytosol] (R-MMU-8851895) Shc1 [cytosol] (R-MMU-1169488) Shc1 [cytosol] (R-MMU-1169451) Shc1 [cytosol] (R-MMU-1248757) phospho-Shc1 [cytosol] (R-MMU-1433476) phospho-Shc1 [cytosol] (R-MMU-8934453) p-Y-Shc1 [cytosol] (R-MMU-8983175) Shc1 [plasma membrane] (R-MMU-2404166) Shc1 [plasma membrane] (R-MMU-2404179) Shc1 [plasma membrane] (R-MMU-2404168) phospho-Shc1 [cytosol] (R-MMU-8934452)	0.899	8
UniProt:Q9QYY0 Gab1	5	phospho-Gab1 [cytosol] (R-MMU-8855306) phospho-Gab1 [cytosol] (R-MMU-180496) Gab1 [cytosol] (R-MMU-9031464) phospho-Gab1 [cytosol] (R-MMU-180344) Gab1 [cytosol] (R-MMU-179795)	0.791	9
UniProt:Q62245 Sos1	4	phospho-Sos1 [cytosol] (R-MMU-109821) Sos1 [cytosol] (R-MMU-443318) Sos1 [plasma membrane] (R-MMU-983559) Sos1 [cytosol] (R-MMU-64847)	0.757	7
UniProt:Q02384	1	Sos2 [cytosol] (R-MMU-167221)	0.678	5
UniProt:O54957	4	phospho-Lat [plasma membrane] (R-MMU-434829) Lat [plasma membrane] (R-MMU-202322) phospho-Lat [plasma membrane] (R-MMU-202364) phospho-Lat [plasma membrane] (R-MMU-2396597)	0.669	5
UniProt:P18052	1	Ptpra [plasma membrane] (R-MMU-388755)	0.656	4
UniProt:P22682 Cbl	8	Cbl [cytosol] (R-MMU-9680636) p-Y-Cbl [cytosol] (R-MMU-9680645) phospho-Cbl [cytosol] (R-MMU-8875457) phospho-Cbl [plasma membrane] (R-MMU-182923) phospho-Cbl [cytosol] (R-MMU-182940) phospho-Cbl [cytosol] (R-MMU-8848826) phospho-Cbl [cytosol] (R-MMU-912656) Cbl [cytosol] (R-MMU-112199)	0.643	7
UniProt:P35329	3	Cd22 [plasma membrane] (R-MMU-5690736) Cd22 [plasma membrane] (R-MMU-197703) phospho-Cd22 [plasma membrane] (R-MMU-5690726)	0.623	4
UniProt:P04925 Prnp	2	Major prion protein [plasma membrane] (R-MMU-420340) Prnp [cytosol] (R-MMU-9617597)	0.618	7
UniProt:Q61234	1	Snta1 [plasma membrane] (R-MMU-5490334)	0.618	3
UniProt:P35235 Ptpn11	5	p-Y546,Y584-Shp2 [cytosol] (R-MMU-443116) Ptpn11 [cytosol] (R-MMU-210002) Ptpn11 [nucleoplasm] (R-MMU-8937745) Ptpn11 [cytosol] (R-MMU-162563) phospho-Ptpn11 [cytosol] (R-MMU-162573)	0.59	3
UniProt:P98078	3	Dab2 [cytosol] (R-MMU-8862456) Dab2 [lysosomal membrane] (R-MMU-2980807) Dab2 [plasma membrane] (R-MMU-2980808)	0.576	4
UniProt:Q60749	3	phospho-Khdrbs1 [cytosol] (R-MMU-8848995) phospho-Khdrbs1 [nucleoplasm] (R-MMU-8848970) Khdrbs1 [nucleoplasm] (R-MMU-8848941)	0.573	2
UniProt:Q61824 Adam12	2	ADAM 12 metalloprotease [plasma membrane] (R-MMU-179841) Adam12 [plasma membrane] (R-MMU-179792)	0.571	3
UniProt:Q62077 Plcg1	10	p-Y-Plcg1 [cytosol] (R-MMU-9029083) Plcg1 [cytosol] (R-MMU-9638030) p-4Y-Plcg1 [plasma membrane] (R-MMU-9030452) phospho-Plcg1 [plasma membrane] (R-MMU-1169084) phospho-Plcg1 [cytosol] (R-MMU-202357) Plcg1 [plasma membrane] (R-MMU-167682) P-Plcg1 [cytosol] (R-MMU-1251936) Plcg1 [plasma membrane] (R-MMU-1251925) Plcg1 [cytosol] (R-MMU-202320) phospho-Plcg1 [plasma membrane] (R-MMU-167679)	0.564	2
UniProt:Q02858 Tek	4	Phosphorylated_Tie2 [plasma membrane] (R-MMU-211116) Tie2 [plasma membrane] (R-MMU-211118) Tek [plasma membrane] (R-MMU-197755) phospho-Tek [plasma membrane] (R-MMU-204772)	0.548	3
UniProt:Q3TTA7	1	Cblb [cytosol] (R-MMU-976009)	0.527	6
UniProt:Q8C180 Frs2	6	phospho-Frs2 [plasma membrane] (R-MMU-170959) Frs2 [plasma membrane] (R-MMU-170963) phospho-Frs2 [plasma membrane] (R-MMU-1270462) phospho-Frs2 [cytosol] (R-MMU-190355) Frs2 [cytosol] (R-MMU-443125) p-Y-Frs2 [cytosol] (R-MMU-9031970)	0.527	5
UniProt:Q52KG5	1	Kif26a [cytosol] (R-MMU-984675)	0.508	2
UniProt:P34152 Ptk2	13	phospho-Ptk2 [cytosol] (R-MMU-354128) phospho-Ptk2 [cytosol] (R-MMU-354068) Ptk2 [cytosol] (R-MMU-201621) Ptk2 [cytosol] (R-MMU-202827) Ptk2 [cytosol] (R-MMU-202829) phospho-Ptk2 [cytosol] (R-MMU-5218694) phospho-Ptk2 [cytosol] (R-MMU-5229006) phospho-Ptk2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) p-Y428-FAK1 [cytosol] (R-MMU-3928397) phospho-Ptk2 [cytosol] (R-MMU-9632393) phospho-Ptk2 [cytosol] (R-MMU-8874600) phospho-Ptk2 [cytosol] (R-MMU-8874613)	0.508	2
UniProt:Q3U1F9	2	Pag1 [plasma membrane] (R-MMU-180500) phospho-Pag1 [plasma membrane] (R-MMU-180494)	0.499	5
UniProt:Q9DD03 Rab13	4	GGC-Rab13 [cytoplasmic vesicle membrane] (R-MMU-1445096) Rab13 [cell junction] (R-MMU-8876591) Rab13 [cytosol] (R-MMU-8873767) Rab13 [cytosol] (R-MMU-8873674)	0.463	2

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