Reactome | Pik3cb [cytosol]

Pik3cb [cytosol]

Stable Identifier

R-MMU-74788

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

PIK3CB, Q8BTI9

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - RET signaling (Mus musculus)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Regulation of T cell activation by CD28 family (Mus musculus)
    - Co-stimulation by CD28 (Mus musculus)
      - CD28 dependent PI3K/Akt signaling (Mus musculus)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        PI3K binds CD28 (Mus musculus)
        
        CD28:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
    - Co-stimulation by ICOS (Mus musculus)
      - PI3K binds ICOS (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        ICOS:PI3K [plasma membrane] (Mus musculus)
        
        Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
  - TCR signaling (Mus musculus)
    - Downstream TCR signaling (Mus musculus)
      - PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)
        
        PI3K bound to TRAT [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
      - Recruitment of PI3K to plasma membrane (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        PI3K bound to TRAT [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-2 family signaling (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
      - 14-3-3 zeta binding allows recruitment of PI3K (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
      - Regulation of signaling by CBL (Mus musculus)
        
        CBL ubiquitinates PI3K (Mus musculus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        K63polyUb-PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Mus musculus)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
        
        PI3K beta [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
- Innate Immune System (Mus musculus)
  - DAP12 interactions (Mus musculus)
    - DAP12 signaling (Mus musculus)
      - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
  - Fc epsilon receptor (FCERI) signaling (Mus musculus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Mus musculus)
      - PI3K associates with phosphorylated GAB2 (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
    - Role of phospholipids in phagocytosis (Mus musculus)
      - PI3K binds to p-6Y-SYK (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
      - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        PI3K [cytosol] (Mus musculus)
        
        PI3K-catalytic subunit [cytosol] (Mus musculus)
        
        Pik3cb [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8BTI9 Pik3cb

Gene Names

Pik3cb

Chain

chain:1-1064

Reference Genes

BioGPS Gene:74769 Pik3cb

KEGG:mmu:74769 Pik3cb

Monarch:74769 Pik3cb

NCBI Gene:74769 Pik3cb

UCSC:Q8BTI9 Pik3cb

Reference Transcript

Other Identifiers

10595924

115741_at

1453069_at

17530000

4318633

4326785

4388966

4555052

4558669

4614466

4695985

4729905

4759021

4818979

4823407

4837722

4850516

4860023

4874203

4897976

4903587

4908579

4918833

4946980

4950278

4955342

4998623

5003246

5010661

5062806

5097165

5103556

5113678

5252195

5256424

5278466

5350406

5353883

5368067

5449021

5485873

5588841

5594982

5598192

74769

A_51_P479914

A_52_P581110

A_55_P2743735

GE38398

GO:0001935

GO:0001952

GO:0002931

GO:0003376

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005886

GO:0005942

GO:0005943

GO:0006629

GO:0006874

GO:0006897

GO:0006914

GO:0007155

GO:0007156

GO:0010595

GO:0010628

GO:0016192

GO:0016301

GO:0016303

GO:0016740

GO:0030168

GO:0030496

GO:0031526

GO:0033031

GO:0035005

GO:0035022

GO:0036092

GO:0040016

GO:0043226

GO:0043231

GO:0043409

GO:0043491

GO:0043560

GO:0045429

GO:0046854

GO:0046934

GO:0048015

GO:0051898

GO:0060055

GO:0106310

GO:0140096

GO:1900747

GO:1903298

GO:1903671

ILMN_1246890

ILMN_2680549

Msa.33438.0_s_at

mMC002172

Participates

as a component of

as a member of

PI3K-catalytic subunit [cytosol] (Mus musculus)

Other forms of this molecule

Pik3cb [cytosol]

Inferred From

PIK3CB [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_011241131.1, XP_011241132.1, NP_083370.2

ENSEMBL

ENSMUSP00000035037, ENSMUST00000035037

PRO

Q8BTI9

GlyGen

Q8BTI9

MGI

1922019

PDB

4BFR, 2Y3A

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26450 Pik3r1	5	p-Y-Pik3r1 [cytosol] (R-MMU-9680631) Pik3r1 [cytosol] (R-MMU-3080572) Pi3k-p85 alpha [cytosol] (R-MMU-1295777) Pik3r1 [cytosol] (R-MMU-74789) Pik3r1 [plasma membrane] (R-MMU-198365)	0.573	5
UniProt:P60766 Cdc42	3	CDC42 [endoplasmic reticulum membrane] (R-MMU-5672086) Cdc42 [plasma membrane] (R-MMU-448841) CDC42 [cytosol] (R-MMU-442630)	0.524	3

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