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Pik3r1 [cytosol]
Stable Identifier
R-MMU-74789
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
PIK3R1, P26450
Locations in the PathwayBrowser for interactor UniProt:Q8IZP0 ABI1
Expand all
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GP1b-IX-V activation signalling (Mus musculus)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Mus musculus)
Pik3r1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
Active FLT3:p-Y-GRB10 binds PIK3R1 (Mus musculus)
Pik3r1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by FGFR (Mus musculus)
Signaling by FGFR1 (Mus musculus)
Downstream signaling of activated FGFR1 (Mus musculus)
PI-3K cascade:FGFR1 (Mus musculus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)
Pik3r1 [cytosol] (Mus musculus)
Signaling by FGFR2 (Mus musculus)
Downstream signaling of activated FGFR2 (Mus musculus)
PI-3K cascade:FGFR2 (Mus musculus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)
Pik3r1 [cytosol] (Mus musculus)
Signaling by FGFR3 (Mus musculus)
Downstream signaling of activated FGFR3 (Mus musculus)
PI-3K cascade:FGFR3 (Mus musculus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)
Pik3r1 [cytosol] (Mus musculus)
Signaling by FGFR4 (Mus musculus)
Downstream signaling of activated FGFR4 (Mus musculus)
PI-3K cascade:FGFR4 (Mus musculus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)
Pik3r1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P26450 Pik3r1
Gene Names
Pik3r1
Chain
initiator methionine:, chain:2-724
Reference Genes
BioGPS Gene:18708 Pik3r1
ENSEMBL:ENSMUSG00000041417.16 Pik3r1
KEGG Gene (Mus musculus):18708 Pik3r1
Monarch:18708 Pik3r1
NCBI Gene:18708 Pik3r1
UCSC:P26450 Pik3r1
Reference Transcript
RefSeq:NM_001077495.2 Pik3r1
Other Identifiers
10411782
113019_at
129853_at
1425514_at
1425515_at
1438682_at
1451737_at
163548_at
17295796
18708
4488390
4509795
4574844
4584747
4627475
4630640
4670222
4701241
4723068
4754477
4792657
4803871
4813365
5041143
5109065
5110986
5173919
5293013
5338577
5432805
5450486
5452837
5519462
96592_at
A_51_P511236
A_52_P235476
A_52_P307938
A_52_P407239
GE1396611
GE33132
GO:0001678
GO:0001784
GO:0001934
GO:0001953
GO:0002376
GO:0002687
GO:0003013
GO:0003824
GO:0005102
GO:0005158
GO:0005159
GO:0005161
GO:0005168
GO:0005515
GO:0005516
GO:0005634
GO:0005737
GO:0005783
GO:0005794
GO:0005801
GO:0005829
GO:0005911
GO:0005942
GO:0005943
GO:0005975
GO:0006006
GO:0006351
GO:0006355
GO:0006366
GO:0006606
GO:0006629
GO:0006886
GO:0006913
GO:0007010
GO:0007155
GO:0007162
GO:0007165
GO:0008286
GO:0008625
GO:0008630
GO:0010459
GO:0010592
GO:0010628
GO:0010656
GO:0012501
GO:0015031
GO:0016020
GO:0016303
GO:0016740
GO:0019209
GO:0019221
GO:0019901
GO:0019903
GO:0019904
GO:0022408
GO:0023052
GO:0030154
GO:0030183
GO:0030316
GO:0030331
GO:0030335
GO:0030971
GO:0031625
GO:0032760
GO:0032868
GO:0032869
GO:0032991
GO:0033120
GO:0034143
GO:0034330
GO:0034644
GO:0034976
GO:0035014
GO:0035655
GO:0036092
GO:0036211
GO:0036312
GO:0042307
GO:0043066
GO:0043125
GO:0043226
GO:0043491
GO:0043559
GO:0043560
GO:0045663
GO:0045671
GO:0045776
GO:0045861
GO:0045944
GO:0046488
GO:0046854
GO:0046935
GO:0046982
GO:0048009
GO:0048471
GO:0048661
GO:0048662
GO:0048856
GO:0048870
GO:0050821
GO:0051117
GO:0051219
GO:0051384
GO:0051491
GO:0051492
GO:0051497
GO:0051591
GO:0051965
GO:0060396
GO:0072659
GO:0097529
GO:0098542
GO:0098772
GO:0120183
GO:1900103
GO:1903076
GO:1990578
ILMN_1249335
ILMN_2473531
ILMN_3040050
ILMN_3114641
mMR026375
u50413_s_at
Participates
as a candidate of
RND2 effectors [cytosol] (Mus musculus)
RHOA GAPs [cytosol] (Mus musculus)
RND3 effectors [cytosol] (Mus musculus)
RHOC GAPs [cytosol] (Mus musculus)
RHOV effectors [cytosol] (Mus musculus)
CDC42 GAPs [cytosol] (Mus musculus)
RAC2 GAPs [cytosol] (Mus musculus)
RHOD GAPs [cytosol] (Mus musculus)
RAC1 GAPs [cytosol] (Mus musculus)
RHOF GAPs [cytosol] (Mus musculus)
RHOB GAPs [cytosol] (Mus musculus)
RHOG GAPs [cytosol] (Mus musculus)
RHOJ GAPs [cytosol] (Mus musculus)
RAC3 GAPs [cytosol] (Mus musculus)
RND1 effectors [cytosol] (Mus musculus)
PI3K regulatory subunits [cytosol] (Mus musculus)
as a member of
RHOU effectors [cytosol] (Mus musculus)
PI3K-regulatory subunits [cytosol] (Mus musculus)
PI3K-regulatory subunit [cytosol] (Mus musculus)
as an input of
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Mus musculus)
Active FLT3:p-Y-GRB10 binds PIK3R1 (Mus musculus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)
as a component of
GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Mus musculus)
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Mus musculus)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Mus musculus)
PIK3CD:PIK3R1 [cytosol] (Mus musculus)
PIK3CB:PIK3R1 [cytosol] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Mus musculus)
GRB2:GAB1:PIK3R1 [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
Other forms of this molecule
p-Y-Pik3r1 [cytosol]
Pik3r1 [cytosol]
Pi3k-p85 alpha [cytosol]
Pik3r1 [plasma membrane]
Inferred From
PIK3R1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001070963.1
Ensembl
ENSMUSP00000056774
,
ENSMUST00000055518
,
ENSMUSG00000041417
PRO
P26450
MGI
97583
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35569 Irs1
8
p-Irs1 [cytosol]
(R-MMU-2671869)
phospho-Irs1 [plasma membrane]
(R-MMU-2445090)
Irs1 [plasma membrane]
(R-MMU-2425392)
Phospho-IRS1 (by NTRK1) [cytosol]
(R-MMU-198285)
Irs1 [cytosol]
(R-MMU-198257)
Irs1 [cytosol]
(R-MMU-74769)
phospho-Irs1 [cytosol]
(R-MMU-74772)
phospho-Irs1 [plasma membrane]
(R-MMU-198366)
0.702
3
UniProt:Q8BTI9 Pik3cb
2
Pik3cb [cytosol]
(R-MMU-9027217)
Pik3cb [cytosol]
(R-MMU-74788)
0.573
5
UniProt:P42337 Pik3ca
1
Pik3ca [cytosol]
(R-MMU-9027214)
0.573
7
UniProt:Q8IZP0 ABI1
2
p-5S-ABI1 [cytosol]
(R-HSA-2029034)
ABI1 [cytosol]
(R-HSA-1671643)
0.524
3
UniProt:Q8R5H6
3
Wasf1 [cytosol]
(R-MMU-200965)
phospho-Wasf1 [cytosol]
(R-MMU-5672390)
phospho-Wasf1 [cytosol]
(R-MMU-2029058)
0.499
2
UniProt:Q9WVS0
2
Icos [plasma membrane]
(R-MMU-198144)
phospho-Icos [plasma membrane]
(R-MMU-389927)
0.499
2
UniProt:Q7TMB8
5
Cyfip1 [specific granule lumen]
(R-MMU-6800167)
Cyfip1 [secretory granule lumen]
(R-MMU-6800940)
Cyfip1 [extracellular region]
(R-MMU-6800473)
Cyfip1 [tertiary granule lumen]
(R-MMU-6800176)
Cyfip1 [cytosol]
(R-MMU-5672575)
0.462
2
UniProt:P28660
1
Nckap1 [cytosol]
(R-MMU-200979)
0.462
2
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.462
2
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