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MRN [nucleoplasm]
Stable Identifier
R-MMU-75164
Type
Complex
Species
Mus musculus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
DNA Damage/Telomere Stress Induced Senescence (Mus musculus)
KAT5 acetylates ATM at DNA DSBs (Mus musculus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
KAT5 acetylates ATM at shortened telomeres (Mus musculus)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN activates ATM (Mus musculus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN bound to shortened telomeres activates ATM (Mus musculus)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN complex binds DNA double strand breaks (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN complex binds shortened telomeres (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN complex bound to DNA ends recruits ATM (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN complex bound to shortened telomeres recruits ATM (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
DNA Double Strand Break Response (Mus musculus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Mus musculus)
ATM phosphorylates NBN (Mus musculus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Sensing of DNA Double Strand Breaks (Mus musculus)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
KAT5 acetylates ATM at DNA DSBs (Mus musculus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN activates ATM (Mus musculus)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN complex binds DNA double strand breaks (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN complex bound to DNA ends recruits ATM (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Homology Directed Repair (Mus musculus)
HDR through MMEJ (alt-NHEJ) (Mus musculus)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
LIG3 ligates remaining SSBs in MMEJ (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN and RBBP8 resect DNA DSBs in MMEJ (Mus musculus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN complex binds RBBP8 (Mus musculus)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
MRN recruits LIG3:XRCC1 to MMEJ sites (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Mus musculus)
MRN [nucleoplasm] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Mre11 [nucleoplasm]
(Mus musculus)
Nbn [nucleoplasm]
(Mus musculus)
RAD50 [nucleoplasm]
(Mus musculus)
Participates
as an output of
LIG3 ligates remaining SSBs in MMEJ (Mus musculus)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Mus musculus)
as a component of
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Mus musculus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Mus musculus)
Shortened telomere:MRN [nucleoplasm] (Mus musculus)
DNA DSBs:MRN [nucleoplasm] (Mus musculus)
as an input of
MRN complex binds shortened telomeres (Mus musculus)
MRN complex binds DNA double strand breaks (Mus musculus)
Inferred From
MRN [nucleoplasm]
(Homo sapiens)
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