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Casp8 [cytosol]
Stable Identifier
R-MMU-76158
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
CASP8(385-479), O89110
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
CLEC7A/inflammasome pathway (Mus musculus)
ASC binds Caspase-8 complex (Mus musculus)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Mus musculus)
MALT1:active caspase-8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
MALT1:active caspase-8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Caspase-8 binds MALT (Mus musculus)
MALT1:active caspase-8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Caspase-8 cleaves IL1B precursor (Mus musculus)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Mus musculus)
MALT1:active caspase-8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
TRIF-mediated programmed cell death (Mus musculus)
Caspase-8 processing within TLR4 complex (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
N4BP1 binds IKBKG (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Apoptotic execution phase (Mus musculus)
Apoptotic cleavage of cellular proteins (Mus musculus)
Caspase-mediated cleavage of cytoskeletal proteins (Mus musculus)
Caspase mediated cleavage of vimentin at IDVD (259) (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Caspase-mediated cleavage of plectin-1 (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Translocation of active caspase-8 to the mitochondrial membrane (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Caspase activation via extrinsic apoptotic signalling pathway (Mus musculus)
Caspase activation via Death Receptors in the presence of ligand (Mus musculus)
Caspase-8 processing within TLR4 complex (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Regulation by c-FLIP (Mus musculus)
Caspase-8 and FLIP(L) processing at DISC (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Intrinsic Pathway for Apoptosis (Mus musculus)
Activation, myristolyation of BID and translocation to mitochondria (Mus musculus)
Caspase-8 activates BID by cleavage (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
RIPK1 is cleaved by CASP8 (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
RIPK3 is cleaved by CASP8 (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
RIPK1 is cleaved by CASP8 (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
TRAF1 is cleaved by caspases (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
active caspase-8 [cytosol] (Mus musculus)
Caspase-8 dimer [cytosol] (Mus musculus)
Casp8 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O89110
Gene Names
Casp8
Reference Genes
BioGPS Gene:12370 Casp8
ENSEMBL:ENSMUSG00000026029
ENSEMBL:ENSMUSG00000026029.15 Casp8
KEGG Gene (Mus musculus):12370 Casp8
Monarch:12370 Casp8
NCBI Gene:12370 Casp8
UCSC:O89110 Casp8
Reference Transcript
RefSeq:NM_009812.2 Casp8
RefSeq:NM_001080126.1 Casp8
RefSeq:NM_001277926.1 Casp8
Other Identifiers
102328_at
10346564
12370
1424552_at
17213213
4414187
4466287
4605085
4746757
4857306
5020777
5033743
5086615
5215711
5464876
5566874
5567361
A_51_P247799
GE41643
GO:0001525
GO:0001817
GO:0001841
GO:0002376
GO:0003824
GO:0004175
GO:0004197
GO:0005123
GO:0005164
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006508
GO:0006915
GO:0007507
GO:0008233
GO:0008234
GO:0008625
GO:0008656
GO:0012501
GO:0016485
GO:0016787
GO:0023052
GO:0030154
GO:0030163
GO:0030225
GO:0030690
GO:0031264
GO:0031265
GO:0031625
GO:0032731
GO:0032991
GO:0034612
GO:0035877
GO:0036462
GO:0042802
GO:0042981
GO:0043065
GO:0043123
GO:0043124
GO:0043226
GO:0043525
GO:0044297
GO:0044877
GO:0045088
GO:0045471
GO:0045651
GO:0045862
GO:0048738
GO:0048856
GO:0051603
GO:0051604
GO:0060546
GO:0070243
GO:0070266
GO:0070269
GO:0097110
GO:0097153
GO:0097190
GO:0097191
GO:0097194
GO:0097199
GO:0097264
GO:0097284
GO:0097342
GO:0098542
GO:0098772
GO:0140096
GO:1900119
GO:2001233
GO:2001238
ILMN_1243876
ILMN_3097868
Msa.28381.0_s_at
mMC023356
Participates
as a component of
Caspase-8 dimer [cytosol] (Mus musculus)
Other forms of this molecule
Casp8 [cytosol]
Casp8 [mitochondrial outer membrane]
Casp8 [mitochondrial outer membrane]
Casp8 [cytosol]
Casp8 [cytosol]
Inferred From
CASP8(385-479) [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_033942.1
,
NP_001073595.1
,
NP_001264855.1
IntEnz
3.4.22.61
Ensembl
ENSMUST00000027189
,
ENSMUSP00000127375
,
ENSMUSG00000026029
,
ENSMUSP00000027189
,
ENSMUST00000165549
PRO
O89110
MGI
1261423
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q61160
1
Fadd [cytosol]
(R-MMU-54639)
0.813
6
UniProt:P25446
1
Fas [plasma membrane]
(R-MMU-66248)
0.669
3
UniProt:Q9D8Y7
1
Tnfaip8l2 [cytosol]
(R-MMU-8874472)
0.524
2
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.499
2
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