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APP(672-713) [extracellular region]
Stable Identifier
R-MMU-879340
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
P12023
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Mus musculus)
ECM proteoglycans (Mus musculus)
AGRN binds Beta amyloid fibril via GAG chains (Mus musculus)
AGRN:Beta amyloid fibril [extracellular region] (Mus musculus)
Beta amyloid fibril [extracellular region] (Mus musculus)
APP(672-713), APP(672-711) [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Beta amyloid fibril [extracellular region] (Mus musculus)
APP(672-713), APP(672-711) [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Innate Immune System (Mus musculus)
Advanced glycosylation endproduct receptor signaling (Mus musculus)
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
TRAF6 mediated NF-kB activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
The Ligand:GPCR:Gi complex dissociates (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
G alpha (q) signalling events (Mus musculus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
The Ligand:GPCR:Gq complex dissociates (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
GPCR ligand binding (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
Peptide ligand-binding receptors (Mus musculus)
Formyl peptide receptors bind formyl peptides and many other ligands (Mus musculus)
FPR2 binds FPR2 ligands (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
FPR2:FPR2 ligands [plasma membrane] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
APP(672-713) [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P12023
Reference Genes
ENSEMBL:ENSMUSG00000022892
Participates
as a member of
APP(672-713), APP(672-711) [extracellular region] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
FPR2 ligands [extracellular region] (Mus musculus)
Other forms of this molecule
APP(18-770) [trans-Golgi network membrane]
APP-C99 [cytosol]
APP (535-695) [cytosol]
APP [mitochondrial inner membrane]
APP(18-770) [extracellular region]
APP(18-770) [platelet alpha granule lumen]
APP(18-770) [endosome lumen]
phospho-p-APP [endoplasmic reticulum lumen]
APP [endoplasmic reticulum lumen]
APP(672-711) [extracellular region]
Inferred From
APP(672-713) [extracellular region]
(Homo sapiens)
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P97318
2
phospho-Dab1 [cytosol]
(R-MMU-8855227)
Dab1 [cytosol]
(R-MMU-8855236)
0.704
3
UniProt:Q03157 APLP1
0.667
4
UniProt:Q9WVI9 JIP1
0.621
3
UniProt:P14211 Calr
8
Calreticulin [phagocytic vesicle]
(R-MMU-1236838)
CALR [phagocytic vesicle membrane]
(R-MMU-1236879)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-MMU-8863866)
CALR [endocytic vesicle lumen]
(R-MMU-2239448)
Calreticulin [extracellular region]
(R-MMU-3221763)
CALR [extracellular region]
(R-MMU-2197641)
CALR [endoplasmic reticulum lumen]
(R-MMU-195905)
CALR [lumenal side of endoplasmic reticulum membrane]
(R-MMU-985502)
0.621
4
UniProt:Q06335
4
APLP2 [plasma membrane]
(R-MMU-8848902)
APLP2 [platelet alpha granule membrane]
(R-MMU-8848898)
phospho-p-APLP2 [endoplasmic reticulum lumen]
(R-MMU-8956977)
APLP2 [endoplasmic reticulum lumen]
(R-MMU-8956784)
0.609
3
UniProt:Q9EPL2 CSTN1
0.602
3
UniProt:Q9WVI9-1 MAPK8IP1
0.576
3
UniProt:P98084 APBA2
0.564
2
UniProt:O88307 SORL
0.557
3
UniProt:Q6PHU5
2
Sort1 [Golgi membrane]
(R-MMU-434332)
Sort1 [cytoplasmic vesicle membrane]
(R-MMU-434221)
0.518
3
UniProt:Q9UQF2 JIP1
0.508
2
UniProt:Q9QXJ1
1
Apbb1 [nucleoplasm]
(R-MMU-5683987)
0.508
2
UniProt:Q62108 Dlg4
3
SAP-90 [plasma membrane]
(R-MMU-443606)
Dlg4 [endocytic vesicle membrane]
(R-MMU-416847)
Dlg4 [cytosol]
(R-MMU-6794267)
0.499
4
UniProt:Q61477 NBL1
0.471
2
UniProt:Q9QZS3 Numb
2
Numb [plasma membrane]
(R-MMU-2077469)
Numb [plasma membrane]
(R-MMU-443595)
0.471
2
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