Reactome | Fcho2 [cytosol]

Fcho2 [cytosol]

Stable Identifier

R-MMU-8862260

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

FCHO2, Q3UQN2

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Mus musculus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - ARBB recruits GPCRs into clathrin-coated pits (Mus musculus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
    - Recruitment of AP-2 complex and clathrin (Mus musculus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Mus musculus)
        
        FCHO1,2 dimer [cytosol] (Mus musculus)
        
        FCHO2 dimer [cytosol] (Mus musculus)
        
        Fcho2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q3UQN2

Gene Names

Fcho2

Reference Genes

BioGPS Gene:218503 Fcho2

ENSEMBL:ENSMUSG00000041685

ENSEMBL:ENSMUSG00000041685.17 Fcho2

KEGG Gene (Mus musculus):218503 Fcho2

Monarch:218503 Fcho2

NCBI Gene:218503 Fcho2

UCSC:Q3UQN2 Fcho2

Reference Transcript

RefSeq:NM_172591.3 Fcho2

Other Identifiers

10411464

106833_at

109355_at

111293_at

1437200_at

17295394

218503

4377929

4529531

4545817

4587948

4604901

4617463

4663896

4696822

4734485

4745371

4818790

4853226

4896329

4914291

5042217

5043952

5050694

5118285

5157222

5161853

5226490

5266617

5317589

5353642

5396741

5410366

5458944

5459317

5461582

A_51_P171376

A_52_P50455

A_55_P2066399

GE137801

GO:0001786

GO:0005515

GO:0005546

GO:0005737

GO:0005886

GO:0005905

GO:0006897

GO:0008289

GO:0010324

GO:0016020

GO:0016192

GO:0030136

GO:0031410

GO:0035091

GO:0042802

GO:0043226

GO:0048268

GO:0048488

GO:0061024

GO:0065003

GO:0072583

GO:0072659

GO:0098835

ILMN_2764019

mMC008328

Participates

as a component of

FCHO2 dimer [cytosol] (Mus musculus)

Inferred From

FCHO2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_766179.2

Ensembl

ENSMUST00000109403, ENSMUSP00000105030, ENSMUST00000040340, ENSMUSG00000041685, ENSMUSP00000042959

PRO

Q3UQN2

MGI

3505790

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.557	3
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.557	3

Cite Us!