Reactome | H2az2 [nucleoplasm]

H2az2 [nucleoplasm]

Stable Identifier

R-MMU-8862427

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

H2AFV, Q3THW5

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Prophase (Mus musculus)
      - Condensation of Prophase Chromosomes (Mus musculus)
        
        CDK1 phosphorylates condensin II subunit NCAPD3 (Mus musculus)
        
        Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        PLK1 binds phosphorylated condensin II complex (Mus musculus)
        
        Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        PLK1 hyperphosphorylates Condensin II complex (Mus musculus)
        
        Hyperphosphorylated Condensin II:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
- Chromosome Maintenance (Mus musculus)
  - Nucleosome assembly (Mus musculus)
    - Deposition of new CENPA-containing nucleosomes at the centromere (Mus musculus)
      - RSF complex binds the centromere (Mus musculus)
        
        CCAN:DNA:CASC5:Centromeric nucleosome:RSF complex [nucleoplasm] (Mus musculus)
        
        Centromeric Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Mus musculus)
        
        Centromeric Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
  - Telomere Maintenance (Mus musculus)
    - Inhibition of DNA recombination at telomere (Mus musculus)
      - ATRX:DAXX binds to subtelomeric chromosomal regions (Mus musculus)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Mus musculus)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
      - Histone H3.3 deposition at telomere (Mus musculus)
        
        Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Mus musculus)
        
        Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Mus musculus)
        
        Nucleosome (H3F3A) [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Mus musculus)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular Senescence (Mus musculus)
    - DNA Damage/Telomere Stress Induced Senescence (Mus musculus)
      - Telomere shortening during replicative exhaustion (Mus musculus)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)

DNA Repair (Mus musculus)

- Base Excision Repair (Mus musculus)
  - Base-Excision Repair, AP Site Formation (Mus musculus)
    - Depurination (Mus musculus)
      - Cleavage of the damaged purine (Mus musculus)
        
        NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Mus musculus)
        
        NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
        
        AP-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
        
        Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
      - Recognition and association of DNA glycosylase with site containing an affected purine (Mus musculus)
        
        NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Mus musculus)
        
        Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
        
        Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- Epigenetic regulation of gene expression (Mus musculus)
  - PRC2 methylates histones and DNA (Mus musculus)
    - DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Mus musculus)
      - DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Mus musculus)
        
        PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Mus musculus)
        
        Chromatin with hemimethylC, H3K27me3 [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
      - DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Mus musculus)
        
        PRC2 Core:Chromatin [nucleoplasm] (Mus musculus)
        
        Chromatin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
    - PRC2 recruits DNA methyltransferases (Mus musculus)
      - DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Mus musculus)
        
        PRC2 Core:Chromatin [nucleoplasm] (Mus musculus)
        
        Chromatin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
      - PRC2 Core:Chromatin [nucleoplasm] (Mus musculus)
        
        Chromatin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
    - PRC2 trimethylates histone H3 at lysine-27 (Mus musculus)
      - PRC2:Chromatin (H3K27me3) [nucleoplasm] (Mus musculus)
        
        Chromatin with trimethylated H3K27 [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
      - PRC2:Chromatin [nucleoplasm] (Mus musculus)
        
        Chromatin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX1 (Mus musculus)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Mus musculus)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Mus musculus)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Mus musculus)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Mus musculus)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Mus musculus)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Mus musculus)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Mus musculus)
        
        Histone H2A [nucleoplasm] (Mus musculus)
        
        H2az2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q3THW5 H2az2

Gene Names

H2az2, H2afv, H2av

Chain

initiator methionine:, chain:2-128

Reference Genes

BioGPS Gene:77605 H2az2

ENSEMBL:ENSMUSG00000041126.17 H2az2

KEGG Gene (Mus musculus):77605 H2az2

Monarch:77605 H2az2

NCBI Gene:77605 H2az2

UCSC:Q3THW5 H2az2

Reference Transcript

RefSeq:NM_029938.1 H2az2

Other Identifiers

10384145

115201_at

1428029_a_at

1436596_at

17260357

4580640

5040813

5252693

5274940

5365324

5409202

77605

96710_at

A_51_P472630

A_55_P2099520

A_55_P2099526

GE40353

GO:0000786

GO:0003677

GO:0005198

GO:0005634

GO:0005694

GO:0006325

GO:0030527

GO:0043226

GO:0046982

GO:0060090

ILMN_2688345

ILMN_2688347

ILMN_2703385

aa285607_s_at

mMC016616

Participates

as a candidate of

Histone H2A [nucleoplasm] (Mus musculus)

Other forms of this molecule

Histone H2A.V [nucleoplasm]

Inferred From

H2AFV [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_084214.1

Ensembl

ENSMUSP00000105359, ENSMUST00000109737, ENSMUSG00000041126

PRO

Q3THW5

MGI

1924855

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