Reactome | Fbxl15 [cytosol]

Fbxl15 [cytosol]

Stable Identifier

R-MMU-8862625

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

FBXL15, Q91W61

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Mus musculus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        SCF E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        F-box protein [cytosol] (Mus musculus)
        
        Fbxl15 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q91W61

Gene Names

Fbxl15

Reference Genes

BioGPS Gene:68431 Fbxl15

ENSEMBL:ENSMUSG00000025226

ENSEMBL:ENSMUSG00000025226.12 Fbxl15

KEGG Gene (Mus musculus):68431 Fbxl15

Monarch:68431 Fbxl15

NCBI Gene:68431 Fbxl15

UCSC:Q91W61 Fbxl15

Reference Transcript

RefSeq:NM_133694.2 Fbxl15

Other Identifiers

103594_at

10463625

1417855_at

17359994

4550050

4686667

4768604

5359437

5488243

5493628

68431

A_55_P2004427

GE38381

GO:0000086

GO:0000278

GO:0005515

GO:0005737

GO:0009953

GO:0016567

GO:0019005

GO:0023052

GO:0030163

GO:0030282

GO:0030513

GO:0031146

GO:0036211

GO:0048856

ILMN_2772752

ILMN_2792047

mMC015873

Participates

as a member of

F-box protein [cytosol] (Mus musculus)

Inferred From

FBXL15 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_598455.2

Ensembl

ENSMUST00000026256, ENSMUSP00000026256, ENSMUSG00000025226, ENSMUST00000177667, ENSMUSP00000137489

PRO

Q91W61

MGI

1915681

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