Reactome | Klhl2 [cytosol]

Klhl2 [cytosol]

Stable Identifier

R-MMU-8863217

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

KLHL2, Q8JZP3

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Mus musculus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Klhl2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8JZP3

Gene Names

Klhl2

Reference Genes

BioGPS Gene:77113 Klhl2

ENSEMBL:ENSMUSG00000031605

ENSEMBL:ENSMUSG00000031605.9 Klhl2

KEGG Gene (Mus musculus):77113 Klhl2

Monarch:77113 Klhl2

NCBI Gene:77113 Klhl2

UCSC:Q8JZP3 Klhl2

Reference Transcript

RefSeq:NM_178633.3 Klhl2

Other Identifiers

10578922

111491_at

1426978_at

1458351_s_at

166425_at

17509642

4357914

4384630

4453601

4495606

4570536

4603108

4681480

4784513

4878578

4896764

5131952

5195276

5215120

5291955

5315963

5351632

5448972

5455606

5470174

5472393

5473087

5476162

77113

GE40309

GO:0001725

GO:0001726

GO:0003779

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0008092

GO:0015629

GO:0016567

GO:0030027

GO:0031463

GO:0036211

GO:0042802

GO:0042803

GO:0042995

GO:0043226

GO:0060090

GO:1990756

ILMN_2686047

mMC021980

Participates

as a member of

BTB proteins [cytosol] (Mus musculus)

Inferred From

KLHL2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_848748.2

Ensembl

ENSMUSG00000031605, ENSMUST00000034017, ENSMUSP00000034017

PRO

Q8JZP3

MGI

1924363

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