Reactome | MyrG-Cdk5r1(2-307) [plasma membrane]

MyrG-Cdk5r1(2-307) [plasma membrane]

Stable Identifier

R-MMU-8863426

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

MyrG-p35

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - Semaphorin interactions (Mus musculus)
      - CRMPs in Sema3A signaling (Mus musculus)
        
        Phosphorylation of CRMPs by Cdk5 (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Mus musculus)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Mus musculus)
        
        PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Mus musculus)
        
        Fyn:pCdk5:p35 [plasma membrane] (Mus musculus)
        
        p-Y15-CDK5:p35 [plasma membrane] (Mus musculus)
        
        MyrG-Cdk5r1(2-307) [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] (Mus musculus)
        
        NRP1:PlexinA1-4:FYN:pCdk5:p53 [plasma membrane] (Mus musculus)
        
        PlexinA1-4:FYN:pCdk5:p35 [plasma membrane] (Mus musculus)
        
        Fyn:pCdk5:p35 [plasma membrane] (Mus musculus)
        
        p-Y15-CDK5:p35 [plasma membrane] (Mus musculus)
        
        MyrG-Cdk5r1(2-307) [plasma membrane] (Mus musculus)
        
        Phosphorylation of CRMPs by GSK3beta (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Mus musculus)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Mus musculus)
        
        PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Mus musculus)
        
        Fyn:pCdk5:p35 [plasma membrane] (Mus musculus)
        
        p-Y15-CDK5:p35 [plasma membrane] (Mus musculus)
        
        MyrG-Cdk5r1(2-307) [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P61809 Cdk5r1

Gene Names

Cdk5r1, Cdk5r, Nck5a

Chain

initiator methionine:, chain:2-307, chain:99-307

Reference Genes

BioGPS Gene:12569 Cdk5r1

ENSEMBL:ENSMUSG00000048895.14 Cdk5r1

KEGG Gene (Mus musculus):12569 Cdk5r1

Monarch:12569 Cdk5r1

NCBI Gene:12569 Cdk5r1

UCSC:P61809 Cdk5r1

Reference Transcript

RefSeq:NM_009871.3 Cdk5r1

Other Identifiers

102664_at

10379482

109524_at

109786_at

12569

1421123_at

1421124_at

1433450_at

1433451_at

162928_f_at

17253991

4446089

4704506

4788572

4973737

5053242

5098151

5135071

5394253

5556670

A_52_P371129

A_55_P2156583

A_55_P2173183

GE42614

GO:0000307

GO:0001764

GO:0002020

GO:0003779

GO:0003824

GO:0005509

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006886

GO:0007010

GO:0007155

GO:0007158

GO:0007213

GO:0007411

GO:0007413

GO:0007420

GO:0008092

GO:0009792

GO:0012501

GO:0014069

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016533

GO:0016740

GO:0019901

GO:0021549

GO:0021722

GO:0021766

GO:0021799

GO:0021819

GO:0023052

GO:0030154

GO:0030182

GO:0030424

GO:0030425

GO:0030426

GO:0031175

GO:0031594

GO:0032956

GO:0034330

GO:0035235

GO:0035255

GO:0042995

GO:0043005

GO:0043025

GO:0043197

GO:0043204

GO:0043226

GO:0043231

GO:0043292

GO:0043525

GO:0043539

GO:0045296

GO:0045348

GO:0045892

GO:0046875

GO:0048013

GO:0048471

GO:0048511

GO:0048856

GO:0048870

GO:0051015

GO:0061001

GO:0061575

GO:0070315

GO:0070507

GO:0090314

GO:0098693

GO:0098772

GO:0098793

ILMN_1238963

ILMN_1259339

mMC012185

mMR026812

u89527_s_at

Participates

as an input of

Calpain 1 or Calpain 2 cleaves Cdk5r1 (p35) (Mus musculus)

as a component of

p-Y15-CDK5:p35 [plasma membrane] (Mus musculus)

Other forms of this molecule

Cdk5r1(2-98) [plasma membrane]

Cdk5r1(99-307) [cytosol]

MyrG-Cdk5r1(2-307) [plasma membrane]

Cdk5r1(99-307) [nucleoplasm]

Inferred From

MyrG-CDK5R1(2-307) [plasma membrane] (Homo sapiens)

Modified Residues

Name

N-myristoylglycine at 2

Coordinate

PsiMod Name

N-myristoylglycine [MOD:00068]

PsiMod Definition

A protein modification that effectively converts a glycine residue to N-myristoylglycine.

Cross References

RefSeq

NP_034001.1

Ensembl

ENSMUSP00000099514, ENSMUSG00000048895, ENSMUST00000053413

PRO

P61809

MGI

101764

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49615 Cdk5	4	Cdk5 [nucleoplasm] (R-MMU-8868354) phospho-p-Y15,S159-CDK5 [nucleoplasm] (R-MMU-6805249) Cdk5 [cytosol] (R-MMU-421084) pCdk5 [cytosol] (R-MMU-421092)	0.564	4
UniProt:Q8CFH6 SIK2			0.544	3
UniProt:Q80U04	1	Pja2 [cytosol] (R-MMU-975993)	0.524	2