Reactome | Pacsin3 [cytosol]

Pacsin3 [cytosol]

Stable Identifier

R-MMU-8868270

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

PACSIN3, Q99JB8

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PACSIN dimers [cytosol] (Mus musculus)
        
        PACSIN3 dimer [cytosol] (Mus musculus)
        
        Pacsin3 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q99JB8

Gene Names

Pacsin3

Reference Genes

BioGPS Gene:80708 Pacsin3

ENSEMBL:ENSMUSG00000027257

ENSEMBL:ENSMUSG00000027257.14 Pacsin3

KEGG Gene (Mus musculus):80708 Pacsin3

Monarch:80708 Pacsin3

NCBI Gene:80708 Pacsin3

UCSC:Q99JB8 Pacsin3

Reference Transcript

Other Identifiers

10473861

111525_at

1416995_at

1437834_s_at

162580_at

17373240

4332265

4366047

4400211

4487679

4578867

4673853

4720971

4726160

4729969

4803799

4861885

4894463

4894590

4977595

5004083

5024814

5061042

5140248

5236300

5366997

5380145

5511338

80708

A_51_P282630

A_55_P1968295

GE41552

GO:0005515

GO:0005543

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0006897

GO:0007010

GO:0008092

GO:0008289

GO:0016020

GO:0016192

GO:0019855

GO:0030100

GO:0030163

GO:0031410

GO:0042802

GO:0043226

GO:0045806

GO:0051044

GO:0051926

GO:0061024

GO:0097320

GO:0098772

ILMN_2589015

ILMN_2628066

ILMN_2639744

ILMN_2639746

ILMN_2693815

mMC007454

mMR028256

Participates

as a component of

PACSIN3 dimer [cytosol] (Mus musculus)

Inferred From

PACSIN3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001276607.1, XP_006500488.1, XP_006500491.1, XP_006500487.1, XP_006500490.1, NP_083009.1, NP_112019.2, NP_001276606.1

Ensembl

ENSMUST00000168916, ENSMUST00000111349, ENSMUSG00000027257, ENSMUST00000028694, ENSMUST00000059566, ENSMUSP00000028694, ENSMUSP00000106981, ENSMUSP00000054391, ENSMUSP00000129175

PRO

Q99JB8

MGI

1891410

PDB

3QE6, 3SYV, 3M3W

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