Cdk5:p25 phosphorylates Golga2

Stable Identifier
R-MMU-8868331
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Cdk5:p25 phosphorylates Golga2

In a mouse Alzheimer's disease model, Cdk5, aberrantly activated by binding to p25, phosphorylates the Golgi membrane protein Golga2 (GM130) at serine residue S37, triggering the fragmentation of the Golgi apparatus (Sun et al. 2008). Please note that S37 of Golga2 is sometimes labeled as S25 in the literature because the recombinant Golga2 construct used in the original study of mitotic Golgi fragmentation (Lowe et al. 1998) lacked 12 N-terminal amino acids of Golga2.

Literature References
PubMed ID Title Journal Year
18480410 Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease

Sun, KH, Vincent, F, Johnson, EO, Shah, K, Chavers, AK, de Pablo, Y

Mol. Biol. Cell 2008
Participants
Catalyst Activity

protein serine/threonine kinase activity of Cdk5:p25 [cytosol]

Orthologous Events
Authored
Created
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