In a mouse Alzheimer's disease model, nuclear fragmentation, which precedes neuronal death, is initiated by phosphorylation of nuclear lamins by p25-activated Cdk5. The Cdk5:p25 complex phosphorylates lamin B1 (Lmnb1) at serine residues S24 and S394 (Chang et al. 2011), corresponding to S23 and S393 of human LMNB1, respectively.
de Pablo, Y,
protein serine/threonine kinase activity of Cdk5:p25 [nucleoplasm]