Reactome | Gm6525 [cytosol]

Gm6525 [cytosol]

Stable Identifier

R-MMU-8868805

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RPL36AL, A0A0A6YW33

Locations in the PathwayBrowser

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Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Translation (Mus musculus)
  - Eukaryotic Translation Initiation (Mus musculus)
    - Cap-dependent Translation Initiation (Mus musculus)
      - Formation of a pool of free 40S subunits (Mus musculus)
        
        Release of 40S and 60S subunits from the 80S ribosome (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Mus musculus)
        
        The 60S subunit joins the translation initiation complex (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
        
        eIF5B:GTP is hydrolyzed and released (Mus musculus)
        
        80S:Met-tRNAi:mRNA [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Mus musculus)
      - Dissociation of L13a from the 60s ribosomal subunit (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
        
        60s ribosomal complex lacking L13a subunit [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
  - SRP-dependent cotranslational protein targeting to membrane (Mus musculus)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Mus musculus)
      - SRP:polypeptide+signal:ribosome [cytosol] (Mus musculus)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL36A,RPL36AL [cytosol] (Mus musculus)
        
        Homologues of RPL36AL [cytosol] (Mus musculus)
        
        Gm6525 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:A0A0A6YW33

Gene Names

Gm6525

Reference Genes

ENSEMBL:ENSMUSG00000104043

ENSEMBL:ENSMUSG00000104043.2 Gm6525

Other Identifiers

160081_at

17398565

4670150

5120792

5124744

5434886

5515783

A_55_P1965524

GE1469910

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0022625

GO:0043226

Participates

as a member of

Homologues of RPL36AL [cytosol] (Mus musculus)

Inferred From

RPL36AL [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSMUSG00000104043, ENSMUSP00000141377, ENSMUST00000193882

MGI

3648757

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