Reactome | Igf2r [clathrin-coated endocytic vesicle membrane]

Igf2r [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-MMU-8869091

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

IGF2R, Q07113

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Igf2r [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Igf2r [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Igf2r [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Igf2r [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Igf2r [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Igf2r [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Igf2r [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Igf2r [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Igf2r [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Igf2r [clathrin-coated endocytic vesicle membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q07113

Gene Names

Igf2r

Reference Genes

BioGPS Gene:16004 Igf2r

ENSEMBL:ENSMUSG00000023830

KEGG:mmu:16004 Igf2r

Monarch:16004 Igf2r

NCBI Gene:16004 Igf2r

UCSC:Q07113 Igf2r

Reference Transcript

RefSeq:NM_010515.2 Igf2r

Other Identifiers

10447799

1424111_at

1424112_at

16004

17340845

4318079

4359990

4426281

4436983

4450896

4480086

4502750

4514821

4515976

4542594

4562465

4599055

4604360

4614280

4635135

4647538

4648111

4665655

4670390

4680029

4729461

4755998

4782246

4784304

4796054

4821702

4829555

4902346

4928038

4951002

4964033

4983441

4987490

5040230

5043263

5053227

5101314

5143237

5150175

5153315

5163196

5175014

5188330

5215782

5221108

5234983

5256791

5278823

5298770

5347930

5393696

5416781

5472791

5502271

5573879

5576358

95117_at

GE33011

GO:0000139

GO:0001889

GO:0001965

GO:0001972

GO:0005515

GO:0005520

GO:0005537

GO:0005615

GO:0005634

GO:0005641

GO:0005768

GO:0005769

GO:0005770

GO:0005794

GO:0005802

GO:0005886

GO:0007041

GO:0007186

GO:0007283

GO:0008289

GO:0009791

GO:0009986

GO:0010008

GO:0016020

GO:0019899

GO:0022414

GO:0030118

GO:0030139

GO:0030140

GO:0031100

GO:0031410

GO:0031995

GO:0032526

GO:0038023

GO:0042802

GO:0042981

GO:0043065

GO:0043226

GO:0044794

GO:0048471

GO:0048856

GO:0051219

GO:0060089

GO:1904772

GO:1905394

ILMN_2589275

ILMN_2931096

mMC007221

u04710_s_at

Participates

as a member of

AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Other forms of this molecule

Igf2r [Golgi membrane]

Igf2r [cytoplasmic vesicle membrane]

Igf2r [transport vesicle]

Igf2r [trans-Golgi network membrane]

Igf2r [plasma membrane]

Igf2r [secretory granule membrane]

Inferred From

IGF2R [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSMUSG00000023830, ENSMUST00000024599, ENSMUSP00000024599

PRO

Q07113

MGI

96435

Cite Us!