Reactome | LRP2 [clathrin-coated endocytic vesicle membrane]

LRP2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-MMU-8869099

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

A2ARV4

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        LRP2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:A2ARV4

Reference Genes

BioGPS Gene:14725

ENSEMBL:ENSMUSG00000027070

ENSEMBL:ENSMUSG00000027070.15

KEGG Gene (Mus musculus):14725

Monarch:14725

NCBI Gene:14725

UCSC:A2ARV4

Reference Transcript

RefSeq:NM_001081088.1

Other Identifiers

103377_at

10483439

109339_at

1427133_s_at

1452320_at

14725

17386210

4351981

4361751

4383439

4409961

4431676

4435276

4446317

4453088

4461436

4475876

4482153

4502426

4508313

4540613

4559477

4563022

4603814

4606842

4613217

4615265

4621474

4637635

4649414

4670537

4672633

4674415

4689494

4689893

4704773

4710908

4712918

4725672

4727222

4739044

4799147

4832605

4845157

4845236

4921104

4925719

4931036

4945375

4949813

4984029

5009878

5049051

5058204

5074533

5084318

5122456

5155709

5159117

5160217

5164741

5164805

5191886

5198122

5206882

5224747

5245478

5265332

5276865

5279325

5280003

5291137

5291666

5318309

5333220

5355820

5357374

5378358

5391697

5393664

5394426

5413037

5413164

5438951

5445229

5445663

5450472

5457964

5470341

5493443

5503367

5517115

5542442

5543657

5550713

5552035

5561129

5567214

5582141

5597859

5602499

5611040

A_51_P174921

A_51_P322000

A_52_P285470

A_52_P460882

GE36838

GO:0001822

GO:0001843

GO:0003139

GO:0003148

GO:0003223

GO:0003281

GO:0005215

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005768

GO:0005783

GO:0005794

GO:0005886

GO:0005903

GO:0005905

GO:0006629

GO:0006766

GO:0006897

GO:0006898

GO:0007399

GO:0007507

GO:0007605

GO:0008283

GO:0008584

GO:0009897

GO:0009986

GO:0010165

GO:0012501

GO:0015031

GO:0016020

GO:0016192

GO:0016197

GO:0016324

GO:0016922

GO:0017038

GO:0017124

GO:0020028

GO:0022414

GO:0023052

GO:0030001

GO:0030139

GO:0030154

GO:0030165

GO:0030424

GO:0030425

GO:0030492

GO:0030514

GO:0030900

GO:0031410

GO:0031526

GO:0031904

GO:0031994

GO:0032991

GO:0034311

GO:0035904

GO:0038024

GO:0042359

GO:0042562

GO:0042995

GO:0043066

GO:0043226

GO:0043235

GO:0043491

GO:0044295

GO:0044321

GO:0044877

GO:0045056

GO:0045177

GO:0045807

GO:0046872

GO:0048856

GO:0050750

GO:0050769

GO:0050877

GO:0051087

GO:0055085

GO:0060068

GO:0060976

GO:0060982

GO:0061156

GO:0061642

GO:0070447

GO:0071363

GO:0097242

GO:0140058

GO:0140077

GO:0140318

GO:1904447

ILMN_2735522

ILMN_3117209

Msa.32856.0_s_at

mMC007378

Participates

as a component of

LRP2:DAB2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Other forms of this molecule

LRP2 [plasma membrane]

Inferred From

LRP2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_001074557.1

Ensembl

ENSMUSP00000079752, ENSMUSG00000027070, ENSMUST00000080953

PRO

A2ARV4

MGI

95794

PDB

8EM4, 8EM7

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9D6K5 SYJ2B			0.508	2
UniProt:Q9WVI9 JIP1			0.508	2
UniProt:Q9Z0G0	1	Gipc1 [cytoplasm] (R-MMU-9839329)	0.508	2
UniProt:P97318	2	phospho-Dab1 [cytosol] (R-MMU-8855227) Dab1 [cytosol] (R-MMU-8855236)	0.508	2
UniProt:Q9ERE9 JIP2			0.508	2
UniProt:Q62108 Dlg4	3	SAP-90 [plasma membrane] (R-MMU-443606) Dlg4 [endocytic vesicle membrane] (R-MMU-416847) Dlg4 [cytosol] (R-MMU-6794267)	0.508	2

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