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PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-MMU-8869104
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
clathrin-coated endocytic vesicle membrane
Synonyms
P26361
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Mus musculus)
Membrane Trafficking (Mus musculus)
Clathrin-mediated endocytosis (Mus musculus)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Mus musculus)
Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Mus musculus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Mus musculus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Mus musculus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Mus musculus)
RAB5 and GAPVD1 bind AP-2 (Mus musculus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P26361
Reference Genes
BioGPS Gene:12638
ENSEMBL:ENSMUSG00000041301
KEGG:mmu:12638
Monarch:12638
NCBI Gene:12638
UCSC:P26361
Reference Transcript
RefSeq:XM_006504978.1
RefSeq:NM_021050.2
RefSeq:XM_006504977.1
Other Identifiers
10536563
12638
1420579_s_at
1427767_a_at
17456247
4309461
4348252
4349299
4449055
4506959
4606668
4627978
4679953
4716032
4781931
4795661
4912644
4925701
4932204
4988748
5037883
5072063
5138040
5143493
5161804
5180618
5193971
5217587
5240114
5255937
5303277
5322557
5335432
5375969
5377791
5507352
5511762
5537765
5566774
5568876
5571334
94757_at
94758_s_at
A_51_P305896
A_52_P452881
A_55_P2134022
A_66_P103142
GO:0000166
GO:0003013
GO:0003824
GO:0005215
GO:0005254
GO:0005260
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0005902
GO:0006629
GO:0006695
GO:0006811
GO:0006821
GO:0006833
GO:0006904
GO:0009410
GO:0009986
GO:0015106
GO:0015108
GO:0015701
GO:0016020
GO:0016323
GO:0016324
GO:0016787
GO:0016853
GO:0016887
GO:0019869
GO:0019899
GO:0022414
GO:0030165
GO:0030301
GO:0030321
GO:0030324
GO:0030425
GO:0031410
GO:0031901
GO:0032991
GO:0033005
GO:0034220
GO:0034707
GO:0034976
GO:0035377
GO:0035725
GO:0035774
GO:0042311
GO:0042626
GO:0043025
GO:0043226
GO:0045921
GO:0048240
GO:0048856
GO:0050891
GO:0051087
GO:0051454
GO:0051649
GO:0055037
GO:0055038
GO:0055085
GO:0060081
GO:0070166
GO:0070175
GO:0071320
GO:0071889
GO:0097186
GO:0098772
GO:0106138
GO:0140359
GO:0140657
GO:1902161
GO:1902476
GO:1904322
GO:1904446
GO:1905460
GO:2000077
ILMN_1256747
ILMN_1259577
ILMN_2554279
m69298_s_at
mMC015944
Participates
as a member of
AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Mus musculus)
Other forms of this molecule
PolyUb-CFTR [plasma membrane]
CFTR [lysosomal membrane]
CFTR [Golgi-associated vesicle membrane]
CFTR [endosome membrane]
PolyUb-CFTR [endosome membrane]
CFTR [plasma membrane]
misfolded CFTR [endoplasmic reticulum membrane]
Inferred From
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (PolyUb [cytosol]) at unknown position
Modification
PolyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_066388.1
,
XP_006505041.1
,
XP_006505040.1
ENSEMBL
ENSMUSP00000049228
,
ENSMUSP00000111064
,
ENSMUSP00000116957
,
ENSMUST00000045706
,
ENSMUST00000140407
,
ENSMUST00000115405
PRO
P26361
GlyGen
P26361
MGI
88388
PDB
1R10
,
1R0W
,
3SI7
,
1R0X
,
1XF9
,
1Q3H
,
1XFA
,
1R0Z
,
1R0Y
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19120
8
HSPA8 [cytosol]
(R-BTA-264476)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-BTA-888599)
HSPA8 [plasma membrane]
(R-BTA-936508)
HSPA8 [nucleoplasm]
(R-BTA-5082380)
HSPA8 [secretory granule lumen]
(R-BTA-6801530)
HSPA8 [extracellular region]
(R-BTA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-BTA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-BTA-8932217)
0.558
5
UniProt:P70441 NHRF1
0.463
3
UniProt:Q9WVC8
1
Slc26a3 [plasma membrane]
(R-MMU-425376)
0.463
3
UniProt:P62991 UBIQ
0.463
2
UniProt:Q8CIW6
1
Slc26a6 [plasma membrane]
(R-MMU-425395)
0.463
3
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