Mbtps1 (S1P) cleaves Creb3l2 (BBF2H7)

Stable Identifier
R-MMU-8874231
Type
Reaction [transition]
Species
Mus musculus
Compartment
Golgi membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mbtps1 (S1P) cleaves Creb3l2 (BBF2H7)
Mbtps1 (S1P) cleaves Creb3l2 (BBF2H7) in the luminal domain (Kondo et al. 2007, Kondo et al. 2012). By inference from SREBFs (SREBPs) the cleavage is believed to occur at a RNLL motif at amino acid residue 430. The N-terminal cleavage product remains attached to the Golgi membrane by its transmembrane domain.
Literature References
PubMed ID Title Journal Year
17178827 BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer

Imaizumi, K, Yoshinaga, K, Kanemoto, S, Saito, A, Ogata, M, Hara, H, Nara, S, Hino, S, Kondo, S, Yamashita, A, Murakami, T

Mol. Cell. Biol. 2007
22705851 Activation of OASIS family, ER stress transducers, is dependent on its stabilization

Iwamoto, H, Hino, SI, Oki, M, Nomura, Y, Miyagi, H, Urano, F, Saito, A, Kaneko, M, Izumi, S, Imaizumi, K, Kawasaki, N, Kanemoto, S, Kondo, S, Asada, R

Cell Death Differ. 2012
Participants
Input
Output
Catalyst Activity

serine-type endopeptidase activity of Mbtps1 [Golgi membrane]

Physical Entity
Mbtps1 [Golgi membrane] (Mus musculus)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
MBTPS1 (S1P) cleaves CREB3L2 (Homo sapiens)
Authored
May, B  (2016-05-21)
Reviewed
Schröder, M  (2017-02-25)
Created
May, B  (2016-05-22)
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