Mbtps2 (S2P) cleaves Creb3l2 (BBF2H7)

Stable Identifier
R-MMU-8874239
Type
Reaction [transition]
Species
Mus musculus
Compartment
Golgi membrane, cytosol
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Mbtps2 (S2P) cleaves Creb3l2 (BBF2H7)
Creb3l2 is cleaved near the cytoplasmic face of the transmembrane domain (Kondo et al. 2007, Kondo et al. 2012). Based on homology with other substrates of regulated intramembrane proteolysis, Mbtps2 (S2P) cleaves Creb3l2, releasing the cytoplasmic N-terminal domain into the cytosol..
Literature References
PubMed ID Title Journal Year
17178827 BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer

Imaizumi, K, Yoshinaga, K, Kanemoto, S, Saito, A, Ogata, M, Hara, H, Nara, S, Hino, S, Kondo, S, Yamashita, A, Murakami, T

Mol. Cell. Biol. 2007
22705851 Activation of OASIS family, ER stress transducers, is dependent on its stabilization

Iwamoto, H, Hino, SI, Oki, M, Nomura, Y, Miyagi, H, Urano, F, Saito, A, Kaneko, M, Izumi, S, Imaizumi, K, Kawasaki, N, Kanemoto, S, Kondo, S, Asada, R

Cell Death Differ. 2012
Participants
Input
Output
Catalyst Activity

metalloendopeptidase activity of Mbtps2 [Golgi membrane]

Physical Entity
Mbtps2 [Golgi membrane] (Mus musculus)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
MBTPS2 (S2P) cleaves CREB3L2 (Homo sapiens)
Authored
May, B  (2016-05-21)
Reviewed
Schröder, M  (2017-02-25)
Created
May, B  (2016-05-22)
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