Reactome | Creb3l1 translocates from the endoplasmic reticulum to the Golgi membrane

Creb3l1 translocates from the endoplasmic reticulum to the Golgi membrane

Stable Identifier

R-MMU-8874370

Type

Reaction [omitted]

Species

Mus musculus

Compartment

Golgi membrane, endoplasmic reticulum membrane

ReviewStatus

5/5

General

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Creb3l1 translocates from the endoplasmic reticulum to the Golgi membrane

Creb3l1 (Oasis) is normally short-lived protein located in the endoplasmic reticulum (ER) membrane that is targeted for proteolytic degradation by Hrd1 (Kondo et al. 2005, Murakami et al. 2006, Kondo et al. 2012). During ER stress Creb3l1 becomes stabilized and traffics by an uncharacterized mechanism to the Golgi membrane where it is cleaved by Golgi-resident proteases Mbtps1 (S1P) and Mbtps2 (S2P) (Murakami et al. 2006, Kondo et al. 2012)

Literature References

PubMed ID	Title	Journal	Year
22705851	Activation of OASIS family, ER stress transducers, is dependent on its stabilization Iwamoto, H, Hino, SI, Oki, M, Nomura, Y, Miyagi, H, Urano, F, Saito, A, Kaneko, M, Izumi, S, Imaizumi, K, Kawasaki, N, Kanemoto, S, Kondo, S, Asada, R	Cell Death Differ.	2012
16417584	Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress Imaizumi, K, Kanemoto, S, Saito, A, Ogata, M, Wanaka, A, Kondo, S, Murakami, T	J. Neurochem.	2006
16236796	CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P O'Hare, P, Stirling, J	Mol. Biol. Cell	2006
15665855	OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes Imaizumi, K, Tatsumi, K, Otori, K, Kanemoto, S, Iseki, K, Ogata, M, Wanaka, A, Kondo, S, Murakami, T	Nat. Cell Biol.	2005