Reactome | Lrig1 [plasma membrane]

Lrig1 [plasma membrane]

Stable Identifier

R-MMU-8875434

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Ub-LRIG1, P70193

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by MET (Mus musculus)
    - Negative regulation of MET activity (Mus musculus)
      - EPS15 and HGS bind ubiquitinated MET (Mus musculus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Mus musculus)
        
        MET:Ub-LRIG1 [plasma membrane] (Mus musculus)
        
        Lrig1 [plasma membrane] (Mus musculus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Mus musculus)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Mus musculus)
        
        MET:Ub-LRIG1 [plasma membrane] (Mus musculus)
        
        Lrig1 [plasma membrane] (Mus musculus)
      - USP8 deubiquitinates LRIG1 (Mus musculus)
        
        MET:Ub-LRIG1 [plasma membrane] (Mus musculus)
        
        Lrig1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P70193

Gene Names

Lrig1

Reference Genes

BioGPS Gene:16206 Lrig1

ENSEMBL:ENSMUSG00000030029

ENSEMBL:ENSMUSG00000030029.15 Lrig1

KEGG Gene (Mus musculus):16206 Lrig1

Monarch:16206 Lrig1

NCBI Gene:16206 Lrig1

UCSC:P70193 Lrig1

Reference Transcript

RefSeq:NM_008377.2 Lrig1

Other Identifiers

101970_at

10546510

1419928_at

1434210_s_at

1449893_a_at

16206

17469217

4328492

4364537

4567748

4573331

4604507

4727537

4728053

4755107

4789629

4794403

4858353

4969345

5065078

5070503

5121515

5124706

5210739

5217312

5241999

5315136

5357030

5443769

5476314

5476700

5556162

5578737

A_51_P116137

A_55_P2105100

A_55_P2109997

A_55_P2744324

D78572_s_at

GE34647

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0007605

GO:0016020

GO:0022405

GO:0030312

GO:0031012

GO:0032474

GO:0048856

GO:0050877

GO:0060384

ILMN_2640862

mMC021930

Participates

as a component of

MET:Ub-LRIG1 [plasma membrane] (Mus musculus)

Other forms of this molecule

Lrig1 [plasma membrane]

Inferred From

Ub-LRIG1 [plasma membrane] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (Ub [cytosol]) at unknown position

Modification

Ub [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_032403.2

Ensembl

ENSMUSG00000030029, ENSMUST00000101126, ENSMUSP00000098686, ENSMUST00000204645, ENSMUSP00000144963, ENSMUSP00000032105, ENSMUST00000032105

PRO

P70193

MGI

107935

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35546 Ret	3	Ret [plasma membrane] (R-MMU-9830456) RET [plasma membrane] (R-MMU-8853797) phospho-p-5Y-RET [plasma membrane] (R-MMU-8854162)	0.463	2

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