Mouse Runx3, in complex with its heterodimerization partner Cbfb, binds the promoter of the Rorc (Ror-gamma) gene, encoding nuclear retinoid-related orphan receptor-gamma. The Runx binding site in the mouse Rorc promoter, TGTGGT, is conserved in the human RORC promoter. Human RUNX3 protein can also bind the mouse Rorc promoter. Mouse Runx3 is expressed in innate lymphoid cell lineages ILC1 and ILC3, but not ILC2 (Ebihara et al. 2015).