Il27 [cytosol]

Stable Identifier
R-MMU-8950713
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
Synonyms
Il27a, Il27alpha, Interleukin-27 subunit alpha
General
Experiments where cells were transfected with mouse Interleukin-27 subunit beta (Ebi3) and Interleukin 27 subunit alpha(Il27) showed that Il27 can be secreted as a monomer, whereas Ebi3 is secreted only as a heterodimer of Ebi3 and Il27 (Shimozato et al. 2009). Il27 monomers may antagonize cytokine signaling through Interleukin-6 receptor subunit beta (IL6ST, gp130) and the Interleukin-6 mediated production of Interleukin-17 and Interleukin-10 (Stumhofer et al. 2010).
Literature References
PubMed ID Title Journal Year
21057510 A role for IL-27p28 as an antagonist of gp130-mediated signaling

Goenka, R, Spudy, B, Chen, Y, Grötzinger, J, Elloso, MM, Hunter, CA, Tait, ED, Saris, CJ, Hosken, N, Fielding, CA, Cua, DJ, Rose-John, S, Stumhofer, JS, Cancro, MP, Jones, SA, Jones, ML, Levin, SD, Quinn, WJ, O'Hara, AC

Nat. Immunol. 2010
19740343 The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses

Li, Q, Sato, A, Tagawa, M, Chiyo, M, Ma, G, Kawamura, K, Shimozato, O

Immunology 2009
External Reference Information
External Reference
Gene Names
Il27, Il27a
Chain
signal peptide:1-28, chain:29-234
Reference Transcript
Other Identifiers
10567987
17496338
246779
4391507
4482943
4490734
4884031
5182269
5264822
A_51_P325165
GE132289
GO:0002230
GO:0002376
GO:0005102
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0005829
GO:0006954
GO:0007165
GO:0009617
GO:0009986
GO:0023052
GO:0030154
GO:0032729
GO:0042129
GO:0045087
GO:0045523
GO:0045625
GO:0048018
GO:0048856
GO:0098542
GO:0098772
GO:0140459
ILMN_2630045
mMC009298
Participates
Other forms of this molecule
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