Letm1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)

Stable Identifier
R-MMU-8951834
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Letm1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)

Letm1 exchanges mitochondrial matrix calcium for protons in the intermembrane space (Shao et al. 2016). Knockdown of Letm1, however, caused a reduction in mitochondrial calcium uptake and proton extrusion at low cytosolic calcium concentration (Jiang et al. 2013).

Literature References
PubMed ID Title Journal Year
27669901 Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca(2+)/H(+) antiporter

Shao, J, Fu, Z, Ji, Y, Guan, X, Guo, S, Ding, Z, Yang, X, Cong, Y, Shen, Y

Sci Rep 2016
23716663 Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome

Jiang, D, Zhao, L, Clish, CB, Clapham, DE

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Catalyst Activity

calcium:proton antiporter activity of Letm1 hexamer [mitochondrial inner membrane]

Orthologous Events
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