Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Cul2 [cytosol]
Stable Identifier
R-MMU-8952511
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
G76-NEDD8-K689-CUL2, Q9D4H8
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Neddylation (Mus musculus)
26S proteasome degrades HIFalpha (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Mus musculus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
NEDD8-CRL2 E3 ligase complex [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
NEDD8-CRL2 E3 ligase complex [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Mus musculus)
Cul2 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
Cul2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9D4H8
Gene Names
Cul2
Reference Genes
BioGPS Gene:71745 Cul2
ENSEMBL:ENSMUSG00000024231
ENSEMBL:ENSMUSG00000024231.16 Cul2
KEGG Gene (Mus musculus):71745 Cul2
Monarch:71745 Cul2
NCBI Gene:71745 Cul2
UCSC:Q9D4H8 Cul2
Reference Transcript
RefSeq:XM_006526275.3 Cul2
RefSeq:NM_029402.3 Cul2
RefSeq:XM_006526274.3 Cul2
Other Identifiers
10453575
136193_i_at
136194_f_at
1419765_at
1451231_a_at
17348079
4333337
4360294
4418663
4449833
4470170
4470251
4633819
4687238
4729844
4775929
4790852
4798312
4873500
4969325
4979751
5109796
5116732
5167420
5204576
5286873
5341691
5414716
5415041
5510073
5540296
5573862
5591771
5602244
71745
96232_at
A_51_P496448
A_52_P483544
A_55_P2121076
A_55_P2121081
A_55_P2121082
A_55_P2168417
GE124962
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0006511
GO:0016567
GO:0019005
GO:0019538
GO:0030163
GO:0030674
GO:0030891
GO:0031146
GO:0031461
GO:0031462
GO:0031625
GO:0036211
GO:0043226
GO:0044877
GO:0060090
GO:0140627
GO:0160072
ILMN_1238615
ILMN_1247069
ILMN_2987369
aa182283_s_at
mMC017638
Participates
as a component of
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
NEDD8-CRL2 E3 ligase complex [cytosol] (Mus musculus)
Other forms of this molecule
Cul2 [nucleoplasm]
Cul2 [cytosol]
Inferred From
G76-NEDD8-K689-CUL2 [cytosol]
(Homo sapiens)
Modified Residues
Name
neddylated lysine (monoNEDD8 [cytosol]) at 689 (in Homo sapiens)
Coordinate
689
Modification
monoNEDD8 [cytosol]
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
RefSeq
XP_006526337.1
,
XP_006526338.1
,
NP_083678.2
Ensembl
ENSMUST00000162301
,
ENSMUSG00000024231
,
ENSMUSP00000125403
,
ENSMUST00000025073
,
ENSMUSP00000025073
PRO
Q9D4H8
MGI
1918995
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text