G alpha (i):GTP binds Src

Stable Identifier
R-MMU-8964229
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
G alpha (i):GTP binds Src
G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(i) subunit alpha (Gnai) can bind directly to proto-oncogene tyrosine-protein kinase Src (Src) in vitro and in vivo. This binding results in autophosphorylation of Src and subsequently its activation. Physiologically, the Src family have implications in cell growth and cancer.
Literature References
PubMed ID Title Journal Year
11007482 Src tyrosine kinase is a novel direct effector of G proteins

Lowry, W, Ali, S, Huang, XY, Huang, J, Ma, YC

Cell 2000
Participants
Input
Output
Orthologous Events
G alpha (i):GTP binds SRC (Homo sapiens)
Authored
Varusai, TM  (2020-02-24)
Reviewed
Huang, X  (2018-09-13)
Created
Varusai, TM  (2017-02-16)
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