Reactome | Gnai1 [plasma membrane]

Gnai1 [plasma membrane]

Stable Identifier

R-MMU-8964313

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Guanine nucleotide-binding protein G, GNAI1_MOUSE

Locations in the PathwayBrowser

Expand all

Hemostasis (Mus musculus)

- Platelet activation, signaling and aggregation (Mus musculus)
  - Signal amplification (Mus musculus)
    - ADP signalling through P2Y purinoceptor 12 (Mus musculus)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
      - Gi activation by P2Y purinoceptor 12 (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)

Neuronal System (Mus musculus)

- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
    - GABA receptor activation (Mus musculus)
      - GABA B receptor activation (Mus musculus)
        
        Activation of GABAB receptors (Mus musculus)
        
        Adenylate cyclase inhibitory pathway (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
        
        Dissociation of the Gi alpha:G olf complex (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GDP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        G alpha (i): GTP [plasma membrane] (Mus musculus)
        
        G alpha (i) [plasma membrane] (Mus musculus)
        
        Gnai1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:B2RSH2 Gnai1

Gene Names

Gnai1, Gnai-1

Chain

initiator methionine:, chain:2-354

Reference Genes

BioGPS Gene:14677 Gnai1

ENSEMBL:ENSMUSG00000057614.7 Gnai1

KEGG Gene (Mus musculus):14677 Gnai1

Monarch:14677 Gnai1

NCBI Gene:14677 Gnai1

UCSC:B2RSH2 Gnai1

Reference Transcript

RefSeq:NM_010305.1 Gnai1

Other Identifiers

104412_at

10528227

1427510_at

1434440_at

1454959_s_at

14677

17445735

4463451

4568578

4699797

4715046

5162842

5190813

5193277

5224858

5246500

5287774

5357121

5548283

97195_at

A_51_P367837

A_52_P653585

A_52_P920129

GE1418113

GO:0000166

GO:0000278

GO:0000287

GO:0001664

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005813

GO:0005815

GO:0005834

GO:0005856

GO:0005886

GO:0005938

GO:0007010

GO:0007049

GO:0007165

GO:0007186

GO:0007188

GO:0016020

GO:0016787

GO:0019001

GO:0019003

GO:0023052

GO:0030496

GO:0031683

GO:0031749

GO:0031821

GO:0032794

GO:0032991

GO:0043226

GO:0043949

GO:0046872

GO:0050805

GO:0051301

GO:0060236

GO:0099738

GO:1904322

GO:1904778

ILMN_2592815

Msa.2735.0_s_at

aa500440_at

mMC020639

Participates

as a candidate of

G alpha (i,o) (candidates) [plasma membrane] (Mus musculus)

as a component of

G alpha (i):GTP [plasma membrane] (Mus musculus)

as a member of

G alpha (i) [plasma membrane] (Mus musculus)

Inferred From

GNAI1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_034435.1

Ensembl

ENSMUSG00000057614, ENSMUSP00000074259, ENSMUST00000074694

PRO

B2RSH2

MGI

95771

PDB

7TD2, 8FX5, 7TD1, 7TD3, 7TD0, 7TD4

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q62108 Dlg4	3	SAP-90 [plasma membrane] (R-MMU-443606) Dlg4 [endocytic vesicle membrane] (R-MMU-416847) Dlg4 [cytosol] (R-MMU-6794267)	0.527	2

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