Cdk1 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1

Stable Identifier
R-MMU-8979019
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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Cdk1 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1

Experiments performed on mouse fibroblasts, including both NIH-3T3 cell line and embryonic fibroblasts, have shown that in G0 and early G1 phase p130 (Rbl2) and p107 (Rbl1), respectively, form a complex with the histone deacetylase Hdac1 and directly repress transcription of the Cdk1 gene (Rayman et al. 2002).

Literature References
PubMed ID Title Journal Year
11959842 E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

Rayman, JB, Takahashi, Y, Indjeian, VB, Dannenberg, JH, Catchpole, S, Watson, RJ, te Riele, H, Dynlacht, BD

Genes Dev 2002
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Orthologous Events
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