Reactome | phospho-Stat3 [cytosol]

phospho-Stat3 [cytosol]

Stable Identifier

R-MMU-8982823

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-STAT3, P42227

Locations in the PathwayBrowser for interactor UniProt:P48025 Syk

Expand all

External Reference Information

External Reference

UniProt:P42227 Stat3

Gene Names

Stat3, Aprf

Chain

initiator methionine:, chain:2-770

Reference Genes

BioGPS Gene:20848 Stat3

KEGG:mmu:20848 Stat3

Monarch:20848 Stat3

NCBI Gene:20848 Stat3

UCSC:P42227 Stat3

Reference Transcript

Other Identifiers

10391301

1426587_a_at

1460700_at

17269717

20848

4309728

4314951

4400912

4433360

4438994

4444418

4468798

4479961

4481009

4481594

4516026

4550236

4618361

4677664

4679042

4728349

4759035

4824535

4867037

4898482

4900043

4904562

4910817

4921230

4940799

4958931

5058258

5069598

5088448

5141613

5143533

5157405

5179940

5182064

5182147

5202616

5219551

5235738

5237856

5343169

5364019

5378195

5387158

5411533

5473808

5483912

5522241

5557325

99099_at

99100_at

A_51_P201480

A_52_P569499

A_55_P1991219

GE119376

GE33020

GE38473

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001228

GO:0001659

GO:0002376

GO:0002931

GO:0003677

GO:0003700

GO:0003723

GO:0004879

GO:0005102

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005743

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006606

GO:0006886

GO:0006913

GO:0006952

GO:0006953

GO:0006954

GO:0007005

GO:0007165

GO:0007179

GO:0007259

GO:0008283

GO:0008284

GO:0008285

GO:0010467

GO:0010507

GO:0010575

GO:0010628

GO:0010629

GO:0010730

GO:0014069

GO:0016071

GO:0016310

GO:0019221

GO:0019901

GO:0019903

GO:0019953

GO:0022414

GO:0030154

GO:0030335

GO:0030522

GO:0031490

GO:0031730

GO:0032355

GO:0032731

GO:0032733

GO:0032755

GO:0032757

GO:0032760

GO:0032870

GO:0032991

GO:0033210

GO:0034097

GO:0035019

GO:0035259

GO:0035591

GO:0035723

GO:0038110

GO:0038113

GO:0038154

GO:0038155

GO:0040014

GO:0042127

GO:0042593

GO:0042755

GO:0042789

GO:0042802

GO:0042803

GO:0043226

GO:0043434

GO:0043491

GO:0043565

GO:0044320

GO:0044321

GO:0045648

GO:0045747

GO:0045766

GO:0045820

GO:0045893

GO:0045944

GO:0046902

GO:0046983

GO:0048708

GO:0050728

GO:0050804

GO:0051726

GO:0055091

GO:0060019

GO:0060089

GO:0060090

GO:0060221

GO:0060259

GO:0060396

GO:0060397

GO:0061024

GO:0061629

GO:0070102

GO:0070878

GO:0071345

GO:0071407

GO:0072538

GO:0072540

GO:0090575

GO:0097009

GO:0097398

GO:0097696

GO:0098685

GO:0098978

GO:0099527

GO:0106015

GO:0106222

GO:0140033

GO:0140105

GO:0140110

GO:0140297

GO:0140313

GO:0140610

GO:1900017

GO:1900037

GO:1902728

GO:1902895

GO:1905564

GO:2000635

GO:2000737

GO:2001171

GO:2001223

ILMN_2589790

ILMN_2698046

ILMN_3096144

aa396029_s_at

mMC021060

mMR029005

u06922_s_at

Participates

as an output of

as a component of

as an input of

p-STAT3 dimerizes (Mus musculus)

as a member of

Other forms of this molecule

phospho-Stat3 [nucleoplasm]

phospho-Stat3 [cytosol]

Stat3 [cytosol]

phospho-Stat3 [cytosol]

Stat3 [cytosol]

p-Y705-Stat3 [cytosol]

p(Y705)-Stat3 [nucleoplasm]

phospho-Stat3 [cytosol]

phospho-Stat3 [nucleoplasm]

Inferred From

p-STAT3 [cytosol] (Homo sapiens)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_998825.1, NP_998824.1

ENSEMBL

ENSMUSP00000090342, ENSMUST00000127638, ENSMUST00000092671, ENSMUST00000103114, ENSMUSP00000120152, ENSMUSP00000099403

ZINC - Substances

STAT3_MOUSE

ZINC target

P42227

PRO

P42227

MGI

103038

GlyGen

P42227

ZINC - Predictions - Purchasable

STAT3_MOUSE

PDB

4E68, 3CWG, 1BG1, 4ZIA

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40189 IL6ST	2	p-Y-IL6ST [plasma membrane] (R-HSA-8950439) IL6ST [plasma membrane] (R-HSA-448453)	0.656	4
UniProt:Q00175	3	monoSUMO1-K7,K388,K531-PGR [nucleoplasm] (R-MMU-4341032) PGR [cytosol] (R-MMU-8948964) PGR [nucleoplasm] (R-MMU-3008952)	0.649	4
UniProt:O54784 Dapk3	1	Death-associated protein kinase 3 [cytosol] (R-MMU-418772)	0.645	8
IntAct:EBI-6398447 IL17F			0.643	3
IntAct:EBI-4566324 IL17			0.643	4
UniProt:Foxp3 ENSMUSG00000039521			0.643	3
UniProt:P48025 Syk	8	p-Syk [cytosol] (R-MMU-9676057) phospho-p-Y-SYK [cytosol] (R-MMU-9705732) phospho-p-Y-SYK [plasma membrane] (R-MMU-429432) Syk [cytosol] (R-MMU-442293) p-Y348,Y352,Y525,Y526-Syk [cytosol] (R-MMU-5621123) phospho-p-6Y-SYK [cytosol] (R-MMU-1861712) phospho-p-Y348-SYK [cytosol] (R-MMU-437953) SYK [cytosol] (R-MMU-58268)	0.611	5
UniProt:P42227 Stat3	13	phospho-Stat3 [nucleoplasm] (R-MMU-1112554) phospho-Stat3 [cytosol] (R-MMU-914048) Stat3 [cytosol] (R-MMU-539044) phospho-Stat3 [cytosol] (R-MMU-8983130) Stat3 [cytosol] (R-MMU-914084) p-Y705-Stat3 [cytosol] (R-MMU-914034) p(Y705)-Stat3 [nucleoplasm] (R-MMU-2730582) phospho-Stat3 [cytosol] (R-MMU-539048) phospho-Stat3 [nucleoplasm] (R-MMU-9027589) phospho-Stat3 [nucleoplasm] (R-MMU-9701429) phospho-Stat3 [nucleoplasm] (R-MMU-9701435) phospho-Stat3 [cytosol] (R-MMU-8982823) phospho-Stat3 [nucleoplasm] (R-MMU-8983188)	0.609	3
UniProt:P23927	1	CRYAB [nucleoplasm] (R-MMU-6806336)	0.608	3
UniProt:P70424	12	phospho-p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-MMU-8864084) phospho-p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-MMU-8864090) phospho-p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-MMU-8863841) phospho-p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-MMU-8863836) ERBB2 [plasma membrane] (R-MMU-372889) phospho-p-Y877-ERBB2 [plasma membrane] (R-MMU-1810438) phospho-p-Y-ERBB2 [plasma membrane] (R-MMU-1678589) phospho-p-Y,Y877-ERBB2 [plasma membrane] (R-MMU-1810446) phospho-p-6Y-ERBB2 [plasma membrane] (R-MMU-1963569) phospho-p-7Y-ERBB2 [plasma membrane] (R-MMU-1248698) phospho-p-6Y,Y1112-ERBB2 [plasma membrane] (R-MMU-8864081) phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (R-MMU-8864079)	0.537	4
UniProt:P30084 ECHS1	17	ECHS1 [mitochondrial matrix] (R-HSA-54125) A2V ECHS1 [mitochondrial matrix] (R-HSA-9916688) T180A ECHS1 [mitochondrial matrix] (R-HSA-9916687) A238V ECHS1 [mitochondrial matrix] (R-HSA-9916686) A132T ECHS1 [mitochondrial matrix] (R-HSA-9916665) G195S ECHS1 [mitochondrial matrix] (R-HSA-9916681) K273E ECHS1 [mitochondrial matrix] (R-HSA-9916680) R54H ECHS1 [mitochondrial matrix] (R-HSA-9916676) I66T ECHS1 [mitochondrial matrix] (R-HSA-9916659) D150G ECHS1 [mitochondrial matrix] (R-HSA-9916674) A158D ECHS1 [mitochondrial matrix] (R-HSA-9916689) C225R ECHS1 [mitochondrial matrix] (R-HSA-9916672) N59S ECHS1 [mitochondrial matrix] (R-HSA-9916684) A138V ECHS1 [mitochondrial matrix] (R-HSA-9916683) E77Q ECHS1 [mitochondrial matrix] (R-HSA-9916667) F33S ECHS1 [mitochondrial matrix] (R-HSA-9916682) Q159R ECHS1 [mitochondrial matrix] (R-HSA-9916666)	0.524	3
UniProt:Q64261	3	CDK6 [cytosol] (R-MMU-68336) CDK6 [nucleoplasm] (R-MMU-141283) phospho-p-T177-CDK6 [nucleoplasm] (R-MMU-69628)	0.499	3
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.463	3

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