Proteasome degrades polyubiquitinated Runx2

Stable Identifier
R-MMU-9008115
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Proteasome degrades polyubiquitinated Runx2

In mouse cells, polyubiquitination of Runx2 in the context of the complex of Runx2, Hivep3 (Shn3, Schnurri-3) and Wwp1, leads to proteasome-mediated degradation of Runx2 (Jones et al. 2006).

Literature References
PubMed ID Title Journal Year
16728642 Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3

Jones, DC, Wein, MN, Oukka, M, Hofstaetter, JG, Glimcher, MJ, Glimcher, LH

Science 2006
Participants
Catalyst Activity

endopeptidase activity of Proteasome [cytosol]

Orthologous Events
Authored
Reviewed
Created
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