Proteasome degrades polyubiquitinated Runx2

Stable Identifier
R-MMU-9009438
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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Proteasome degrades polyubiquitinated Runx2

Recombinant mouse Runx2, polyubiquitinated by Smurf1, is degraded by the proteasome (Zhao et al. 2003).

Literature References
PubMed ID Title Journal Year
12738770 E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation

Zhao, M, Qiao, M, Oyajobi, BO, Mundy, GR, Chen, D

J. Biol. Chem. 2003
Participants
Catalyst Activity

endopeptidase activity of Proteasome [cytosol]

Orthologous Events
Authored
Reviewed
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