p-Stat5 dissociates from Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2

Stable Identifier
Reaction [dissociation]
Mus musculus
SVG |   | PPTX  | SBGN
p-Stat5 dissociates from Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2

After being phosphorylated, phospho-Stat5 (Stat5a or Stat5b) dissociates from the Epo:Epor complex, dimerizes, and transits to the nucleus where it activates transcription of target genes (Penta and Sawyer 1995, Klingmuller et al. 1996, Yamamura et al. 1998, Tsuji-Takayama et al. 2006).

Literature References
PubMed ID Title Journal Year
9488432 Erythropoietin and Friend virus gp55 activate different JAK/STAT pathways through the erythropoietin receptor in erythroid cells

Ikawa, Y, Matsuzaki, T, Yamamura, Y, Kageyama, Y, Noda, M, Senda, H

Mol. Cell. Biol. 1998
8710869 Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5

Lodish, HF, Klingm├╝ller, U, Hsiao, JG, Bergelson, S

Proc. Natl. Acad. Sci. U.S.A. 1996
8537396 Erythropoietin induces the tyrosine phosphorylation, nuclear translocation, and DNA binding of STAT1 and STAT5 in erythroid cells

Penta, K, Sawyer, ST

J. Biol. Chem. 1995
16982325 Erythropoietin induces sustained phosphorylation of STAT5 in primitive but not definitive erythrocytes generated from mouse embryonic stem cells

Otani, T, Nakamura, S, Kibata, M, Motoda, R, Orita, K, Inoue, T, Tsuji-Takayama, K

Exp. Hematol. 2006
Orthologous Events
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