phospho-Epor:phospho-Jak2:Lyn:Irs2 binds Stat5

Stable Identifier
Reaction [binding]
Mus musculus
SVG |   | PPTX  | SBGN
phospho-Epor:phospho-Jak2:Lyn:Irs2 binds Stat5

Stat5 (Stat5a or Stat5b) binds the phosphorylated cytoplasmic domain of Epor via phosphotyrosine-343 and phosphotyrosine-479 of Epor (Chin et al. 1996, Gobert et al. 1996, Sawyer and Penta 1996, Damen et al. 1997, Iwatsuki et al. 1997, Barber et al. 2001, Bittorf et al. 2000).

Literature References
PubMed ID Title Journal Year
8977232 Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3

Chin, H, Nakamura, N, Kamiyama, R, Miyasaka, N, Ihle, JN, Miura, O

Blood 1996
8665851 Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation

Gobert, S, Chrétien, S, Gouilleux, F, Muller, O, Pallard, C, Dusanter-Fourt, I, Groner, B, Lacombe, C, Gisselbrecht, S, Mayeux, P

EMBO J. 1996
10676844 Activation of STAT5 during EPO-directed suppression of apoptosis

Bittorf, T, Seiler, J, Lüdtke, B, Büchse, T, Jaster, R, Brock, J

Cell. Signal. 2000
11290583 A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation

Barber, DL, Beattie, BK, Mason, JM, Nguyen, MH, Yoakim, M, Neel, BG, D'Andrea, AD, Frank, DA

Blood 2001
9209412 The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation

Damen, JE, Liu, L, Wakao, H, Miyajima, A, Rosten, P, Jefferson, AB, Majerus, PW, Krosl, J, Humphries, RK, Krystal, G

Leukemia 1997
8943308 Association of JAK2 and STAT5 with erythropoietin receptors. Role of receptor phosphorylation in erythropoietin signal transduction

Sawyer, ST, Penta, K

J. Biol. Chem. 1996
9079629 STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line

Iwatsuki, K, Endo, T, Misawa, H, Yokouchi, M, Matsumoto, A, Ohtsubo, M, Mori, KJ, Yoshimura, A

J. Biol. Chem. 1997
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