Tysnd1 cleaves Scp2

Stable Identifier
R-MMU-9034335
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Tysnd1 cleaves Scp2

The trypsin-like serine-type endopeptidase Tysnd1 cleaves Scp2 between amino acid residues 424 and 425, yielding Scp2(1-424) and Scp2(425-547) (Kurochkin et al. 2007, Mizuno et al. 2013).

Literature References
PubMed ID Title Journal Year
23459139 Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility

Alodaib, AN, Kurochkin, IV, Iwasa, H, Nishimukai, M, Okazaki, Y, Maeba, R, Motegi, H, Jacob, M, Horai, Y, Nakachi, Y, Ninomiya, Y, Tsukui, T, Al Amoudi, M, Hara, H, Wakana, S, Alkuraya, FS, Mizuno, Y, Watanabe, M, Mizuno, Y, Shimozawa, N, Iseki, M, Toshimori, K, Ito, C, Noda, T, Okazaki, T, Schönbach, C, Akita, M

PLoS Genet. 2013
17255948 Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids

Kurochkin, IV, Mizuno, Y, Konagaya, A, Okazaki, Y, Sakaki, Y, Schönbach, C

EMBO J. 2007
Participants
Catalyst Activity

serine-type endopeptidase activity of Tysnd1 [peroxisomal matrix]

Orthologous Events
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