Tysnd1 cleaves Hsd17b4

Stable Identifier
Reaction [transition]
Mus musculus
SVG |   | PPTX  | SBGN
Tysnd1 cleaves Hsd17b4

The trypsin-like serine-type endopeptidase Tysnd1 cleaves Hsd17b4 (Peroxisomal multifunctional enzyme type 2) between amino acid residues 311 and 312, yielding Hsd17b4(1-311) and Hsd17b4(312-735) (Kurochkin et al. 2007, Mizuno et al. 2013). Hsd17b4(1-311) dehydrogenates 3-hydroxyacyl-CoA; Hsd17b4(312-735) acts as an enoyl-CoA hydratase. The uncleaved protein (Hsd17b4) also catalyzes these reactions.

Literature References
PubMed ID Title Journal Year
23459139 Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility

Alodaib, AN, Kurochkin, IV, Iwasa, H, Nishimukai, M, Okazaki, Y, Maeba, R, Motegi, H, Jacob, M, Horai, Y, Nakachi, Y, Ninomiya, Y, Tsukui, T, Al Amoudi, M, Hara, H, Wakana, S, Alkuraya, FS, Mizuno, Y, Watanabe, M, Mizuno, Y, Shimozawa, N, Iseki, M, Toshimori, K, Ito, C, Noda, T, Okazaki, T, Schönbach, C, Akita, M

PLoS Genet. 2013
17255948 Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids

Kurochkin, IV, Mizuno, Y, Konagaya, A, Okazaki, Y, Sakaki, Y, Schönbach, C

EMBO J. 2007
Catalyst Activity

serine-type endopeptidase activity of Tysnd1 [peroxisomal matrix]

Orthologous Events
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