Reactome | phospho-Shc1 [cytosol]

phospho-Shc1 [cytosol]

Stable Identifier

R-MMU-912321

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-Y349,Y350,Y427-SHC1, P98083

Locations in the PathwayBrowser

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Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - RET signaling (Mus musculus)
      - 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
      - SHC1 in the RET complex is phosphorylated (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
      - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
      - p-5Y-RET complexes bind GRB2 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
      - p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-2 family signaling (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC1 recruits SHIP (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC1 recruits SHIP (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P98083-3 Shc1

Gene Names

Shc1, Shc, ShcA

Other Identifiers

104350_at

10493519

10493530

1422853_at

1422854_at

17399432

17399451

20416

4438479

4464752

4597304

4598666

4611903

4781818

4827703

4831049

4843718

4861442

4866348

4978968

5006563

5040489

5077328

5114887

5151032

5151355

5162067

5230211

5234716

5239308

5244996

5279142

5294395

5334342

5347788

5365949

5475784

5525559

5561997

5567359

93713_at

A_52_P384250

A_55_P1979082

A_65_P17586

GE41902

GO:0001525

GO:0001784

GO:0003012

GO:0003013

GO:0005068

GO:0005154

GO:0005158

GO:0005159

GO:0005168

GO:0005515

GO:0005737

GO:0005739

GO:0005759

GO:0005768

GO:0005829

GO:0005886

GO:0005925

GO:0006351

GO:0006355

GO:0006940

GO:0007010

GO:0007155

GO:0007173

GO:0007507

GO:0008284

GO:0008286

GO:0010008

GO:0012501

GO:0016525

GO:0023052

GO:0030036

GO:0030154

GO:0030182

GO:0030971

GO:0031175

GO:0031410

GO:0035556

GO:0042127

GO:0042742

GO:0042802

GO:0043066

GO:0043226

GO:0043410

GO:0044877

GO:0045892

GO:0045893

GO:0045907

GO:0046875

GO:0048009

GO:0048408

GO:0048661

GO:0048856

GO:0051219

GO:0051721

GO:0060090

GO:0070161

GO:0070374

GO:0070435

GO:0071363

GO:0071864

GO:0090322

GO:0098542

GO:0098609

GO:1990839

ILMN_1236765

ILMN_2637676

ILMN_2716426

ILMN_2957070

Msa.1387.0_s_at

aa119070_s_at

mMC021453

mMC025703

mMR029196

Participates

as a candidate of

p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol] (Mus musculus)

as an input of

as an output of

p-3Y-SHC1 dissociates from IGF1R (Mus musculus)

as a component of

Other forms of this molecule

Shc1 [plasma membrane]

p-Y-Shc1-3 [cytosol]

Shc1-3 [cytosol]

phospho-Shc1 [cytosol]

Shc1 [cytosol]

phospho-Shc1 [plasma membrane]

phospho-Shc1 [cytosol]

Shc1 [cytosol]

phospho-Shc1 [cytosol]

Inferred From

p-3Y-SHC1 [cytosol] (Homo sapiens)

p-3Y-SHC1-1,p-3Y-SHC1-2 [cytosol] (Homo sapiens)

p-Y349,Y350,Y427-SHC1-1 [cytosol] (Homo sapiens)

p-Y349,Y350,Y427-SHC1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 427 (in Homo sapiens)

Coordinate

427

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 349 (in Homo sapiens)

Coordinate

349

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 350 (in Homo sapiens)

Coordinate

350

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001106802.1, NP_035498.2

Ensembl

ENSMUSP00000103040, ENSMUSP00000091940, ENSMUST00000094378, ENSMUSP00000140336, ENSMUST00000039110, ENSMUSP00000035361, ENSMUST00000107417, ENSMUSG00000042626, ENSMUST00000191485

PRO

P98083

MGI

98296

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60631 Grb2	3	Grb2 [cytosol] (R-MMU-74686) Grb2 [plasma membrane] (R-MMU-202993) Grb2 [cytosol] (R-MMU-443287)	0.899	8
UniProt:Q9JKF1	3	Iqgap1 [plasma membrane] (R-MMU-381681) Iqgap1 [secretory granule membrane] (R-MMU-6804803) Iqgap1 [cytosol] (R-MMU-5626371)	0.65	5
UniProt:P35831	1	PTPN12 [cytosol] (R-MMU-432933)	0.558	2

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