Telomere clustering at the nuclear membrane

Stable Identifier
Reaction [omitted]
Mus musculus
SVG |   | PPTX  | SBGN
Telomere clustering at the nuclear membrane
As sections of the axial elements form, the telomeres migrate to one site on the inner nuclear membrane to form the telomere bouquet (Scherthan et al. 1996). A current model shows the synaptonemal complex interacting with Sun1 and Sun2, which span the inner membrane and bind Nesprin-1 and Nesprin-2, which span the outer membrane and bind cytoplasmic actin (Padmakumar et al. 2005, Ding et al. 2007, Schmitt et al. 2007). Lamin-B1 and Lamin-C2 are located adjacent to the attachment plate on the inner membrane (Padmakumar et al. 2005, Schmitt et al. 2007).
Literature References
PubMed ID Title Journal Year
17452644 Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope

Stewart, CL, Benavente, R, Alsheimer, M, Höög, C, Hodzic, D, Schmitt, J

Proc Natl Acad Sci U S A 2007
8794855 Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing

Cremer, T, Härle, M, Schwegler, H, Heyting, C, Weich, S, Scherthan, H

J Cell Biol 1996
17543860 SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice

Yu, J, Zhuang, Y, Han, M, Xu, T, Ding, X, Xu, R

Dev Cell 2007
16079285 The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope

Noegel, AA, Padmakumar, VC, Zaim, H, Libotte, T, Abraham, S, Gotzmann, J, Karakesisoglou, I, Foisner, R, Lu, W

J Cell Sci 2005
Orthologous Events
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