Atr Phosphorylates Histone H2A.X at Unsynapsed Regions

Stable Identifier
R-MMU-912423
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Atr Phosphorylates Histone H2A.X at Unsynapsed Regions
The Atr kinase phosphorylates H2A.x at Serine 140 (Turner et al. 2004, Bellani et al. 2005, Mahadevaiah et al. 2008).
Literature References
PubMed ID Title Journal Year
15589157 BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation

Barrett, JC, Xu, X, Aprelikova, O, Wang, R, Chandramouli, GV, Turner, JM, Burgoyne, PS, Deng, CX, Kim, S

Curr Biol 2004
15998665 SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes

Bellani, MA, Camerini-Otero, RD, Cairatti, DA, Romanienko, PJ

J Cell Sci 2005
18663141 Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation

Bourc'his, D, de Rooij, DG, Bestor, TH, Turner, JM, Burgoyne, PS, Mahadevaiah, SK

J Cell Biol 2008
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Synaptonemal Complex:BRCA1:ATR [nucleoplasm]

Physical Entity
Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)
Authored
May, B  (2010-07-03)
Reviewed
Bolcun-Filas, E  (2011-02-25)
Lyndaker, A  (2011-02-25)
Holloway, JK  (2011-02-05)
Schimenti, JC  (2011-02-05)
Strong, E  (2011-02-25)
Cohen, PE  (2011-02-05)
Created
May, B  (2010-07-09)
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