Recruitment of Atr Kinase to Unsynapsed Regions

Stable Identifier
R-MMU-912449
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Recruitment of Atr Kinase to Unsynapsed Regions
Unsynapsed regions of chromosomes accumulate Brca1, the kinase Atr, and the phosphorylated histone gammaH2AX (Keegan et al. 1996, Turner et al. 2004, Bellani et al. 2005, Mahadevaiah et al. 2008). The recruitment of Atr depends on Brca1 (Turner et al. 2004).
Literature References
PubMed ID Title Journal Year
8843195 The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes

Flaggs, G, Plug, AW, Meyn, MS, Ashley, T, Moss, SB, Taylor, EM, Brainerd, EE, Keegan, KS, Bentley, NJ, Hoekstra, MF, Christenson, ER, Holtzman, DA, Carr, AM

Genes Dev 1996
15589157 BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation

Barrett, JC, Xu, X, Aprelikova, O, Wang, R, Chandramouli, GV, Turner, JM, Burgoyne, PS, Deng, CX, Kim, S

Curr Biol 2004
15998665 SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes

Bellani, MA, Camerini-Otero, RD, Cairatti, DA, Romanienko, PJ

J Cell Sci 2005
18663141 Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation

Bourc'his, D, de Rooij, DG, Bestor, TH, Turner, JM, Burgoyne, PS, Mahadevaiah, SK

J Cell Biol 2008
Participants
Input
Output
Orthologous Events
ATR Kinase is recruited to unsynapsed regions (Homo sapiens)
Authored
May, B  (2010-07-03)
Reviewed
Bolcun-Filas, E  (2011-02-25)
Lyndaker, A  (2011-02-25)
Holloway, JK  (2011-02-05)
Schimenti, JC  (2011-02-05)
Strong, E  (2011-02-25)
Cohen, PE  (2011-02-05)
Created
May, B  (2010-07-09)
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