Recruitment of Atr Kinase to Unsynapsed Regions

Stable Identifier
R-MMU-912449
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Recruitment of Atr Kinase to Unsynapsed Regions

Unsynapsed regions of chromosomes accumulate Brca1, the kinase Atr, and the phosphorylated histone gammaH2AX (Keegan et al. 1996, Turner et al. 2004, Bellani et al. 2005, Mahadevaiah et al. 2008). The recruitment of Atr depends on Brca1 (Turner et al. 2004).

Literature References
PubMed ID Title Journal Year
15589157 BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation

Turner, JM, Aprelikova, O, Xu, X, Wang, R, Kim, S, Chandramouli, GV, Barrett, JC, Burgoyne, PS, Deng, CX

Curr Biol 2004
8843195 The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes

Keegan, KS, Holtzman, DA, Plug, AW, Christenson, ER, Brainerd, EE, Flaggs, G, Bentley, NJ, Taylor, EM, Meyn, MS, Moss, SB, Carr, AM, Ashley, T, Hoekstra, MF

Genes Dev 1996
15998665 SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes

Bellani, MA, Romanienko, PJ, Cairatti, DA, Camerini-Otero, RD

J Cell Sci 2005
18663141 Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation

Mahadevaiah, SK, Bourc'his, D, de Rooij, DG, Bestor, TH, Turner, JM, Burgoyne, PS

J Cell Biol 2008
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Orthologous Events
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