Shp2 can recruit Grb2

Stable Identifier
R-MMU-914067
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Shp2 can recruit Grb2
SHP2 can associate with GRB2 (Stein-Gerlach et al. 1995). IL-3 induces the phosphorylation of SHP2 and its association with GRB2 (Welham et al. 1994). SHP2 may act as a scaffold protein to recruit other signaling molecules, e.g. SHP2 was reported to link GRB2 to the receptor tyrosine kinase c-kit (Tauchi et al. 1994).
Literature References
PubMed ID Title Journal Year
7522233 Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase

Dechert, U, Jirik, F, Leslie, KB, Schrader, JW, Welham, MJ

J Biol Chem 1994
7559570 Protein-tyrosine phosphatase 1D modulates its own state of tyrosine phosphorylation

Stein-Gerlach, M, Ullrich, A, Kharitonenkov, A, Ali, S, Vogel, W

J Biol Chem 1995
Participants
Input
Output
Orthologous Events
SHP2 can recruit GRB2 (Homo sapiens)
Authored
Ray, KP  (2010-05-17)
Reviewed
Hercus, TR  (2010-09-06)
Lopez, AF  (2010-09-06)
Created
Jupe, S  (2010-07-21)
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