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Traf3 [cytosol]
Stable Identifier
R-MMU-914241
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
TRAF3, Q60803
Locations in the PathwayBrowser for interactor UniProt:Q9Y2R2 PTPN22
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
TNFR2 non-canonical NF-kB pathway (Mus musculus)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Mus musculus)
Traf3 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Mus musculus)
TRAF3 binds TICAM1:activated TLR4 complex (Mus musculus)
Traf3 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q60803
Gene Names
Traf3
Reference Genes
BioGPS Gene:22031 Traf3
ENSEMBL:ENSMUSG00000021277
KEGG:mmu:22031 Traf3
Monarch:22031 Traf3
NCBI Gene:22031 Traf3
UCSC:Q60803 Traf3
Reference Transcript
RefSeq:XM_006515799.1 Traf3
RefSeq:XM_006515800.2 Traf3
RefSeq:XM_006515801.2 Traf3
RefSeq:NM_011632.3 Traf3
RefSeq:XM_006515798.2 Traf3
Other Identifiers
10398618
1418587_at
1449149_at
17279070
22031
4411283
4434182
4521632
4543992
4563378
4578581
4602839
4633084
4649670
4651009
4665662
4733013
4807387
4823687
4899045
4941212
4982667
5049868
5128394
5128770
5158908
5316875
5333576
5546373
5587913
5591944
95010_at
A_51_P469411
A_55_P2092968
GE42177
GE42677
GO:0001817
GO:0002224
GO:0002376
GO:0003824
GO:0004842
GO:0005164
GO:0005515
GO:0005737
GO:0005739
GO:0005768
GO:0006355
GO:0006915
GO:0007165
GO:0008063
GO:0008270
GO:0009898
GO:0010008
GO:0012501
GO:0016740
GO:0019901
GO:0019903
GO:0030162
GO:0031410
GO:0031625
GO:0031996
GO:0032088
GO:0032481
GO:0032648
GO:0033209
GO:0034142
GO:0035631
GO:0042802
GO:0042981
GO:0043122
GO:0043226
GO:0045087
GO:0046872
GO:0050688
GO:0061630
GO:0070534
GO:0098542
GO:0140096
ILMN_2439638
ILMN_3066172
ILMN_3144289
mMC015227
u33840_s_at
Participates
as a member of
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Mus musculus)
as an output of
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Mus musculus)
as a component of
TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
as an input of
TRAF3 binds TICAM1:activated TLR4 complex (Mus musculus)
Other forms of this molecule
Traf3 [cytosol]
Traf3 [cytosol]
Inferred From
TRAF3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006515861.1
,
XP_006515862.1
,
XP_006515863.1
,
NP_035762.2
,
XP_006515864.1
ENSEMBL
ENSMUSP00000021706
,
ENSMUST00000021706
IntEnz
2.3.2.27
PRO
Q60803
MGI
108041
PDB
4GHU
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22366
1
Myd88 [cytosol]
(R-MMU-166059)
0.677
5
UniProt:P62991 UBIQ
0.589
2
UniProt:Q9UHD2 TBK1
5
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
p-TBK1 [cytosol]
(R-HSA-9008705)
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
0.589
2
UniProt:Q80UF7
1
Ticam1 [cytosol]
(R-MMU-166170)
0.589
2
UniProt:Q9Y2R2 PTPN22
1
PTPN22 [cytosol]
(R-HSA-8852205)
0.544
5
UniProt:Q8VCF0 Mavs
2
Mavs/Ips-1/Cardif/Visa [mitochondrial outer membrane]
(R-MMU-936455)
Mavs [mitochondrial outer membrane]
(R-MMU-913730)
0.524
4
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