Reactome | K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

Stable Identifier

R-MMU-937016

Type

Complex

Species

Mus musculus

Compartment

endosome membrane

Locations in the PathwayBrowser

Expand all

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

x 2 K63polyUb-RIPK1 [cytosol] (Mus musculus)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)

Participates

as an input of

IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Mus musculus)

as a component of

CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)

as an output of

K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Mus musculus)

This entity regulates

Negatively

TLR4-induced ripoptosome assembly (Mus musculus)

Inferred From

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)

Cite Us!