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K63polyUb-RIPK1 [cytosol]
Stable Identifier
R-MMU-937021
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q60855
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF(TICAM1)-mediated TLR4 signaling (Mus musculus)
IKK complex recruitment mediated by RIP1 (Mus musculus)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Mus musculus)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Mus musculus)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TRIF-mediated programmed cell death (Mus musculus)
TLR4-induced ripoptosome assembly (Mus musculus)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ovarian tumor domain proteases (Mus musculus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Mus musculus)
TNFAIP3:K63polyUb-RIPK1 [cytosol] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
Ub-specific processing proteases (Mus musculus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Mus musculus)
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Mus musculus)
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
CLIP3 and CYLD bind TNF signaling complex (Mus musculus)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
K63polyUb-RIPK1 is deubiquitinated (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
LUBAC ubiquitinates RIPK1 at K627 (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNFR1-induced NFkappaB signaling pathway (Mus musculus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63polyUb-RIPK1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q60855
Reference Genes
BioGPS Gene:19766
ENSEMBL:ENSMUSG00000021408
ENSEMBL:ENSMUSG00000021408
KEGG Gene (Mus musculus):19766
Monarch:19766
NCBI Gene:19766
UCSC:Q60855
Reference Transcript
RefSeq:XM_006516607.3
RefSeq:NM_009068.3
RefSeq:XM_006516609.3
Other Identifiers
10404506
130183_at
1419508_at
1439273_at
1449485_at
17286472
19766
4387682
4499854
4576677
4587400
4619144
4679401
4705696
4738836
4769386
4792006
4886540
4937728
4942812
4968495
4977703
5073064
5165706
5165855
5170973
5475993
5598996
5609742
97091_at
AA186144_at
A_51_P430952
A_52_P174775
A_52_P452740
GE33576
GO:0000165
GO:0000166
GO:0001934
GO:0002376
GO:0004672
GO:0004674
GO:0004706
GO:0005123
GO:0005515
GO:0005524
GO:0005622
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006807
GO:0006915
GO:0006954
GO:0007165
GO:0008219
GO:0010940
GO:0010942
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030163
GO:0031047
GO:0031264
GO:0031625
GO:0032757
GO:0032760
GO:0032991
GO:0034612
GO:0036211
GO:0036289
GO:0042327
GO:0042802
GO:0042803
GO:0043065
GO:0043066
GO:0043068
GO:0043123
GO:0043124
GO:0043170
GO:0043226
GO:0043235
GO:0043410
GO:0044238
GO:0044877
GO:0045121
GO:0045651
GO:0045944
GO:0046330
GO:0046777
GO:0048856
GO:0050729
GO:0051092
GO:0055085
GO:0060545
GO:0060546
GO:0065003
GO:0070105
GO:0070231
GO:0070266
GO:0070301
GO:0070513
GO:0070926
GO:0071310
GO:0071356
GO:0071363
GO:0097191
GO:0097300
GO:0097342
GO:0097343
GO:0097527
GO:0106310
GO:0140096
GO:1901026
GO:1903265
GO:1903800
GO:1905206
GO:1990000
GO:2000377
GO:2001237
GO:2001238
GO:2001240
ILMN_2753492
U25995_s_at
mMR026803
Participates
as a component of
TNFAIP3:K63polyUb-RIPK1 [cytosol] (Mus musculus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Mus musculus)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
as a member of
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Mus musculus)
Other forms of this molecule
K48polyUb-RIPK1 [cytosol]
PolyUb-RIPK1 [cytosol]
RIPK1 [cytosol]
phospho-p-S166-RIPK1 [cytosol]
phospho-p-S357-RIPK1 [cytosol]
phospho-p-S320-RIPK1 [cytosol]
phospho-K63,M1polyUb, p-T189-RIPK1 [cytosol]
polyUb-K377,K604,K634-RIPK1 [cytosol]
RIPK1(325-671) [cytosol]
RIPK1(1-324) [cytosol]
K63,M1polyUb-RIPK1 [cytosol]
phospho-K63,Met1-polyUb, p-S25-RIPK1 [cytosol]
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
Inferred From
K63polyUb-RIPK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 377 (in Homo sapiens)
Coordinate
377
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_006516672.1
,
NP_033094.3
,
XP_006516670.1
Ensembl
ENSMUSP00000129831
,
ENSMUSG00000021408
,
ENSMUSP00000021844
,
ENSMUST00000021844
,
ENSMUST00000167374
PRO
Q60855
MGI
108212
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q61160
1
Fadd [cytosol]
(R-MMU-54639)
0.886
8
UniProt:P25118
1
TNFRSF1A(30-45) [plasma membrane]
(R-MMU-5675738)
0.669
3
UniProt:P62991 UBIQ
0.667
5
UniProt:Q9QZL0
8
phospho-p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-MMU-9686933)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-MMU-9794180)
OGlcNAc-T467-RIPK3 [cytosol]
(R-MMU-9687819)
RIPK3(329-518) [cytosol]
(R-MMU-9686937)
RIPK3(1-328) [cytosol]
(R-MMU-9686917)
Ub-K55,363-RIPK3 [cytosol]
(R-MMU-9688825)
phospho-p-S199,227-RIPK3 [cytosol]
(R-MMU-5218873)
RIPK3 [cytosol]
(R-MMU-450328)
0.589
4
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.499
3
UniProt:Q3U0V2
1
TRADD [cytosol]
(R-MMU-66376)
0.499
2
UniProt:P33896 Ifnar1
3
Ifnar1 [plasma membrane]
(R-MMU-912671)
Ifnar1 [plasma membrane]
(R-MMU-877334)
phospho-Ifnar1 [plasma membrane]
(R-MMU-909675)
0.463
2
UniProt:P47741
1
Tnfrsf4 [plasma membrane]
(R-MMU-5692210)
0.462
7
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